HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: FLII (Q13045)
Protein flightless-1 homolog
Gene: FLII

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Gelsolin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 1269
+	Hs
		891735 ACTB_HUMAN (1-375): 0: 604: 98.93		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		932132 ACTC_HUMAN (2-375): 0: 595: 94.39		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		413941 ACTBL_HUMAN (2-375): 0: 734: 91.44		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413874 ACTB_HUMAN (1-375): 0: 604: 98.93		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413884 ACTG_HUMAN (1-375): 0: 604: 100.00		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413885 ACTC_HUMAN (2-375): 0: 595: 94.39		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413881 ACTA_HUMAN (2-375): 0: 594: 94.39		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413886 ACTS_HUMAN (2-375): 0: 594: 93.85		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Dm
		501491 ACT1_DROME (2-375): 0: 600: 98.13		QUAI_DROME (496-1261): 3.23e-158: 498: 17.64
+	Hs
		1122544 ACTBL_HUMAN (2-375): 0: 734: 91.44		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Oc
		101997 ACTB_RABIT (1-375): 0: 602: 98.67		G1U9R8_RABIT (886-1269): 3e-82: 287: 19.70
+	Hs
		892149 ACTB_HUMAN (1-375): 0: 604: 98.93		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		930076 ACTG_HUMAN (1-375): 0: 604: 100.00		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		932481 ACTC_HUMAN (2-375): 0: 595: 94.39		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		915546 ACTA_HUMAN (2-375): 0: 594: 94.39		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		933081 ACTS_HUMAN (2-375): 0: 594: 93.85		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Dm
		950116 ACT6_DROME (2-375): 0: 596: 95.46		FLII_DROME (2-305): 2.17e-61: 232: 26.06
+	Hs
		313786 ACTB_HUMAN (1-375): 0: 604: 98.93		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Bt
		221227 ACTB_BOVIN (1-375): 0: 604: 98.93		SVIL_BOVIN (1056-1266): 2.8e-21: 103: 16.60