Protein: AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)]

Gene: AIMP1
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q12904

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0001525 - angiogenesis
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0005125 - cytokine activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1089294

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

7

1

Small-scale

0.750

High

926458

SYRC
Arginine--tRNA ligase, cytoplasmic

6

3

Small-scale

0.732

High

1089340

OPTN
Optineurin

4

1

High-throughput

0.698

High

563692

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

1089302

SYK
Lysine--tRNA ligase

3

9

Small-scale

0.662

High

140242

SDCB1
Syntenin-1

3

0

High-throughput

0.638

High

60502

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

5

High-throughput

0.628

High

214199

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

2

3

High-throughput

0.628

High

460512

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

10

High-throughput

0.628

High

576757

SYDC
Aspartate--tRNA ligase, cytoplasmic

2

8

High-throughput

0.628

High

834436

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

7

High-throughput

0.628

High

868146

SYQ
Glutamine--tRNA ligase

2

7

High-throughput

0.628

High

940229

SYMC
Methionine--tRNA ligase, cytoplasmic

2

11

High-throughput

0.628

High

1089358

SYLC
Leucine--tRNA ligase, cytoplasmic

2

8

High-throughput

0.628

High

1089324

HOME1
Homer protein homolog 1

2

2

High-throughput

0.606

High

1089323

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

0

High-throughput

0.585

High

1089336

CSN5
COP9 signalosome complex subunit 5

2

0

High-throughput

0.585

High

241532

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

507892

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

1

Small-scale

0.584

High

799050

BRCA1
Breast cancer type 1 susceptibility protein

2

1

High-throughput

0.584

High

1089347

ACE2
Angiotensin-converting enzyme 2

2

1

High-throughput

0.584

High

400736

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

557263

SRC
Proto-oncogene tyrosine-protein kinase Src

2

1

High-throughput

0.571

High

1089352

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

2

Small-scale

0.561

High

881043

NASP
Nuclear autoantigenic sperm protein

2

0

High-throughput

0.559

High

1089341

DDRGK
DDRGK domain-containing protein 1

2

0

Small-scale

0.559

High

853666

MK08
Mitogen-activated protein kinase 8

1

1

Small-scale

0.550

High

1089345

TSNAX
Translin-associated protein X

1

0

High-throughput

0.549

High

218127

TGON2
Trans-Golgi network integral membrane protein 2

2

0

High-throughput

0.547

High

1089308

CP135
Centrosomal protein of 135 kDa

2

0

High-throughput

0.547

High

215553

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.536

High

317633

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.536

High

391609

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

484511

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

687666

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

5

High-throughput

0.536

High

1089297

CUL1
Cullin-1

1

1

High-throughput

0.536

High

1089365

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

352419

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

459279

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

573454

ENPL
Endoplasmin

1

3

Small-scale

0.515

High

692946

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

271511

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

471000

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.513

High

886473

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

1089299

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1089300

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1089325

GCC2
GRIP and coiled-coil domain-containing protein 2

1

0

High-throughput

0.513

High

1089328

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1089329

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

1089332

STYX
Serine/threonine/tyrosine-interacting protein

1

0

Small-scale

0.513

High

1089344

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

0

High-throughput

0.513

High

1089372

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

1089373

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

846903

ETV4
ETS translocation variant 4

1

1

High-throughput

0.500

High

1008546

ELF3
ETS-related transcription factor Elf-3

1

1

High-throughput

0.500

High

1089370

EMC9
ER membrane protein complex subunit 9

1

1

High-throughput

0.489

High

422015

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

964254

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

131998

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

170109

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

302501

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.479

High

371894

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

404016

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

406118

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

411829

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

425475

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

560383

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

606698

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

609992

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

650144

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.479

High

720206

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.479

High

731241

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

754826

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

787008

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

2

High-throughput

0.479

High

891498

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

964897

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

970415

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

975007

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

979573

H4
Histone H4

1

1

High-throughput

0.479

High

980732

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

1031354

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

1035575

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1049144

RON
Macrophage-stimulating protein receptor

1

2

High-throughput

0.479

High

1089293

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

1089295

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1089296

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1089298

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

1089301

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1089316

SND1
Staphylococcal nuclease domain-containing protein 1

1

1

High-throughput

0.479

High

1089319

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1089334

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1089337

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1089349

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.479

High

1089354

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1089356

ANLN
Anillin

1

1

High-throughput

0.479

High

1089359

TRM7
tRNA

1

1

High-throughput

0.479

High

1089360

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1089364

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

165316

PSA7
Proteasome subunit alpha type-7

1

0

Small-scale

0.458

High

179883

BET1
BET1 homolog

1

0

High-throughput

0.458

High

194163

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

227526

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

272125

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

289985

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

315524

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

380014

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

537065

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

659454

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

766501

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

861137

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

867083

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

872268

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

929926

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

957720

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

986378

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1024537

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1067241

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1089303

FSCN1
Fascin

1

0

High-throughput

0.458

High

1089304

AMOT
Angiomotin

1

0

High-throughput

0.458

High

1089305

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

1089306

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.458

High

1089309

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1089311

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1089313

RFIP1
Rab11 family-interacting protein 1

1

0

Small-scale

0.458

High

1089315

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1089318

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1089321

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1089327

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1089331

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1089335

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1089339

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1089343

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1089346

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1089353

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1089355

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1089357

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1089361

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

1089366

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1089371

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.458

High

429800

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1089307

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1089310

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

1089367

ST38L
Serine/threonine-protein kinase 38-like

1

1

High-throughput

0.445

High

293633

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

879024

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1089314

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1089320

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1089333

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

1089350

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1089363

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

653282

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1086568

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.426

High

1089348

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

1089351

VIAAT
Vesicular inhibitory amino acid transporter

1

0

High-throughput

0.426

High

1089317

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

1089362

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

1089312

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1089322

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

1089326

MILK2
MICAL-like protein 2

1

0

High-throughput

0.249

Low

1089330

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1089338

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.249

Low

1089368

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1089369

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.249

Low

1089342

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025