HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	9563508, 21336309
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 1512
+	Hs
		1028455 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		849319 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		919719 UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		895785 UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		851810 UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Zm
		13349 A0A1D6FSE0_MAIZE (4-157): 1.37e-74: 221: 35.71		A0A1Q0ZG94_MAIZE (840-1510): 2.6e-121: 413: 18.54
+	At
		1105323 SCE1_ARATH (2-155): 5.4e-72: 215: 66.23		KIN10_ARATH (1228-1509): 1.62e-124: 400: 29.33
+	Zm
		35309 A0A1D6LKH6_MAIZE (1-154): 6.82e-67: 202: 38.31		A0A1Q0ZG94_MAIZE (840-1510): 2.6e-121: 413: 18.54
+	Zm
		8408 A0A1D6ENM7_MAIZE (2-157): 5.13e-75: 223: 35.90		Q6RXY1_MAIZE (1229-1509): 8.04e-118: 382: 27.31
+	Hs
		625339 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		625230 UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		930367 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		M3K5_HUMAN (1249-1503): 1.95e-40: 166: 37.31
+	Zm
		15814 A0A1D6LKH6_MAIZE (1-154): 6.82e-67: 202: 38.31		A0A1D6GGI2_MAIZE (1242-1511): 2.1e-42: 169: 35.87
+	Sc
		618341 UBC7_YEAST (1-149): 9.95e-31: 110: 38.13		STE11_YEAST (1208-1506): 9.69e-48: 185: 34.71