HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: M3K5 (Q99683)
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
Gene: MAP3K5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16142216
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 1374
+	Hs
		850627 UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07		KS6A3_HUMAN (623-1074): 1.34e-117: 387: 19.83
+	At
		1105323 SCE1_ARATH (2-155): 5.4e-72: 215: 66.23		KIN10_ARATH (663-1136): 9.51e-116: 374: 17.78
+	Hs
		930446 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		KS6A6_HUMAN (673-1074): 2.65e-113: 375: 21.31
+	Hs
		851392 UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12		NEK4_HUMAN (680-1303): 2.63e-113: 378: 19.70
+	Hs
		160499 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		AURKA_HUMAN (551-947): 1.43e-115: 369: 22.36
+	Dm
		959121 Q7KNM2_DROME (1-158): 1.41e-66: 201: 85.44		KCC2A_DROME (678-1086): 2.78e-112: 365: 21.98
+	Zm
		15814 A0A1D6LKH6_MAIZE (1-154): 6.82e-67: 202: 38.31		A0A1D6GGI2_MAIZE (684-1032): 1.28e-101: 343: 32.77
+	Hs
		1039098 Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	Hs
		131560 UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07		STK25_HUMAN (686-1026): 1.88e-97: 321: 31.29
+	Hs
		930200 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		KCC2D_HUMAN (678-995): 1.4e-97: 324: 26.53
+	Hs
		1028455 UB2D4_HUMAN (4-157): 3.74e-75: 222: 34.42		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		849319 UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		919719 UB2D2_HUMAN (4-157): 2.44e-74: 220: 35.07		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		895785 UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		930188 UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31
+	Hs
		851810 UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12		M3K1_HUMAN (686-933): 1.47e-40: 166: 37.31