Protein: AAKG1
5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)

Gene: AAKG1, PRKAG1
Organism: Homo sapiens
Interactions: 159
UniProt ID: P54619

Gene Ontology (top 5):
GO:0004679 - AMP-activated protein kinase activity
GO:0004691 - cAMP-dependent protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

930300

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

20

20

Small-scale

0.990

High

225548

AAKB2
5'-AMP-activated protein kinase subunit beta-2

14

18

Small-scale

0.985

High

930283

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

15

20

Small-scale

0.985

High

930386

AAKB1
5'-AMP-activated protein kinase subunit beta-1

13

17

Small-scale

0.982

High

930379

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

3

16

Small-scale

0.849

High

771866

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.702

High

930353

DCR1C
Protein artemis

4

2

High-throughput

0.694

High

930308

KEAP1
Kelch-like ECH-associated protein 1

3

2

High-throughput

0.675

High

279132

ULK1
Serine/threonine-protein kinase ULK1

3

18

Small-scale

0.667

High

585776

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

3

11

High-throughput

0.662

High

930346

TEKT1
Tektin-1

3

0

High-throughput

0.646

High

930315

AT2B3
Plasma membrane calcium-transporting ATPase 3

3

0

High-throughput

0.638

High

930317

TBB8
Tubulin beta-8 chain

3

0

High-throughput

0.638

High

930344

GLMP
Glycosylated lysosomal membrane protein

3

0

High-throughput

0.638

High

260681

CUTA
Protein CutA

3

0

High-throughput

0.634

High

930348

TRI11
E3 ubiquitin-protein ligase TRIM11

2

2

High-throughput

0.628

High

930352

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

2

8

High-throughput

0.628

High

930297

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

3

0

High-throughput

0.622

High

930321

LTOR1
Ragulator complex protein LAMTOR1

3

0

High-throughput

0.622

High

930374

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

2

1

High-throughput

0.611

High

893680

MEOX1
Homeobox protein MOX-1

2

4

High-throughput

0.606

High

930296

KRA11
Keratin-associated protein 1-1

2

9

High-throughput

0.606

High

930307

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

2

1

High-throughput

0.606

High

930358

KR412
Keratin-associated protein 4-12

2

9

High-throughput

0.606

High

930359

KRA98
Keratin-associated protein 9-8

2

9

High-throughput

0.606

High

930360

KRA92
Keratin-associated protein 9-2

2

9

High-throughput

0.606

High

930341

FNIP1
Folliculin-interacting protein 1

2

1

Small-scale

0.601

High

241195

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

536823

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.584

High

685136

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

930282

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

14

High-throughput

0.575

High

930376

STIM2
Stromal interaction molecule 2

2

1

High-throughput

0.574

High

930361

KRA42
Keratin-associated protein 4-2

1

9

High-throughput

0.573

High

930366

PKHF2
Pleckstrin homology domain-containing family F member 2

2

2

High-throughput

0.553

High

658818

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

2

High-throughput

0.553

High

245205

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.536

High

365341

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.536

High

687652

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

2

High-throughput

0.536

High

887865

MCM2
DNA replication licensing factor MCM2

1

5

High-throughput

0.536

High

930294

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

2

High-throughput

0.536

High

930301

NDK3
Nucleoside diphosphate kinase 3

1

3

High-throughput

0.536

High

930303

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

3

High-throughput

0.536

High

930309

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

930310

DSC3
Desmocollin-3

1

1

High-throughput

0.536

High

930356

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.536

High

930385

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

2

High-throughput

0.536

High

646799

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.518

High

930351

AP1S3
AP-1 complex subunit sigma-3

1

0

High-throughput

0.518

High

830410

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

280560

PR40A
Pre-mRNA-processing factor 40 homolog A

1

8

High-throughput

0.515

High

930288

KR105
Keratin-associated protein 10-5

1

9

High-throughput

0.515

High

930290

KR10B
Keratin-associated protein 10-11

1

9

High-throughput

0.515

High

930320

Q6FHY5
MEOX2 protein

1

4

High-throughput

0.515

High

652295

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.513

High

772596

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.513

High

839533

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

930304

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

930314

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.513

High

930330

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

930364

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

930369

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

930370

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.513

High

930372

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

930383

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.513

High

295122

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

2

High-throughput

0.508

High

930293

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.501

High

930299

ACACA
Acetyl-CoA carboxylase 1

1

3

Small-scale

0.501

High

930354

CRBN
Protein cereblon

1

1

Small-scale

0.501

High

861950

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.500

High

930285

CASP6
Caspase-6

1

0

High-throughput

0.493

High

930350

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

893773

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

930286

KR101
Keratin-associated protein 10-1

1

9

High-throughput

0.481

High

930287

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.481

High

930289

KR109
Keratin-associated protein 10-9

1

9

High-throughput

0.481

High

930384

KLH20
Kelch-like protein 20

1

2

Small-scale

0.481

High

930336

FLCN
Folliculin

1

0

Small-scale

0.479

High

131855

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

209883

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

1

High-throughput

0.479

High

244842

TRAK2
Trafficking kinesin-binding protein 2

1

7

High-throughput

0.479

High

293423

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315329

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

318679

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.479

High

320646

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

519875

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

588300

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

629683

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

664515

ALAT1
Alanine aminotransferase 1

1

1

High-throughput

0.479

High

674976

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

695028

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

767788

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

878834

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

930284

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

930291

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

930292

RAC1
Ras-related C3 botulinum toxin substrate 1

1

1

High-throughput

0.479

High

930295

DUSP2
Dual specificity protein phosphatase 2

1

3

Small-scale

0.479

High

930305

CUL3
Cullin-3

1

1

High-throughput

0.479

High

930306

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

930312

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

930313

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.479

High

930316

ZXDC
Zinc finger protein ZXDC

1

1

High-throughput

0.479

High

930324

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

930325

ASB18
Ankyrin repeat and SOCS box protein 18

1

1

High-throughput

0.479

High

930326

TMTC3
Protein O-mannosyl-transferase TMTC3

1

5

High-throughput

0.479

High

930327

AHSA2
Putative activator of 90 kDa heat shock protein ATPase homolog 2

1

2

High-throughput

0.479

High

930328

SYPM
Probable proline--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

930345

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

930357

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

7

Small-scale

0.479

High

930362

RHBT2
Rho-related BTB domain-containing protein 2

1

4

High-throughput

0.479

High

930363

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

930365

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

930367

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.479

High

930378

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

930382

SOX13
Transcription factor SOX-13

1

1

High-throughput

0.479

High

930387

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

1

High-throughput

0.479

High

322812

MTCL2
Microtubule cross-linking factor 2

1

9

Small-scale

0.470

High

208483

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.458

High

279317

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

363028

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

477742

PKHD1
Fibrocystin

1

0

High-throughput

0.458

High

930302

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.458

High

930332

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.458

High

930340

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.458

High

930355

INT14
Integrator complex subunit 14

1

0

High-throughput

0.458

High

930368

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

930373

SAGE1
Sarcoma antigen 1

1

0

High-throughput

0.458

High

930381

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.458

High

194814

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

1

Small-scale

0.457

High

563476

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

Small-scale

0.457

High

327880

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.445

High

409326

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

930298

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.445

High

930311

SL9A5
Sodium/hydrogen exchanger 5

1

2

High-throughput

0.445

High

930319

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

930322

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

930331

LIPB1
Liprin-beta-1

1

4

High-throughput

0.445

High

930333

ULK2
Serine/threonine-protein kinase ULK2

1

14

High-throughput

0.445

High

930342

S20A1
Sodium-dependent phosphate transporter 1

1

1

High-throughput

0.445

High

930377

FNIP2
Folliculin-interacting protein 2

1

1

Small-scale

0.445

High

930388

S4A7
Sodium bicarbonate cotransporter 3

1

3

High-throughput

0.445

High

930389

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

3

High-throughput

0.445

High

930339

SFXN5
Sideroflexin-5

1

1

High-throughput

0.437

High

930347

ENTR1
Endosome-associated-trafficking regulator 1

1

1

High-throughput

0.437

High

930349

TMX3
Protein disulfide-isomerase TMX3

1

2

High-throughput

0.437

High

877651

SL9A3
Sodium/hydrogen exchanger 3

1

2

High-throughput

0.407

High

930371

S22AB
Solute carrier family 22 member 11

1

1

High-throughput

0.407

High

930380

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.407

High

930318

MFS4B
Sodium-dependent glucose transporter 1

3

0

High-throughput

0.347

High

732920

GASR
Gastrin/cholecystokinin type B receptor

3

0

High-throughput

0.345

High

930323

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.299

High

930329

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

930335

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

930337

RFESD
Rieske domain-containing protein

1

0

High-throughput

0.279

Low

930343

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

930334

CFA46
Cilia- and flagella-associated protein 46

1

0

High-throughput

0.249

Low

930338

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.249

Low

930375

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.249

Low

628400

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025