HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: PP4R1 (Q8TF05)
Serine/threonine-protein phosphatase 4 regulatory subunit 1
Gene: PPP4R1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.779

Property	Details
Experiments	26496610, 27880917, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HEAT~Metallophos
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 950
+	Hs
		915244 PP2AB_HUMAN (1-309): 0: 528: 97.41		PP4R1_HUMAN (1-950): 0: 1060: 100.00
+	Hs
		890987 PP4C_HUMAN (4-309): 0: 508: 64.82		PP4R1_HUMAN (1-950): 0: 1060: 100.00
+	Bt
		61642 PP4C_BOVIN (4-309): 0: 508: 64.82		F1MRS1_BOVIN (18-950): 0: 1025: 83.87
+	Sp
		619320 PP2A2_SCHPO (5-309): 0: 504: 79.02		2AAA_SCHPO (4-385): 1.52e-29: 126: 13.37
+	Sp
		619310 PP2A1_SCHPO (7-309): 1.75e-179: 499: 79.54		2AAA_SCHPO (4-385): 1.52e-29: 126: 13.37
+	Sc
		618757 PP2A1_YEAST (10-309): 0: 517: 76.00		2AAA_YEAST (190-836): 1.35e-15: 83.4: 15.05
+	Sc
		618820 PP2A2_YEAST (10-309): 0: 514: 76.67		2AAA_YEAST (190-836): 1.35e-15: 83.4: 15.05
+	Hs
		672079 PP2AA_HUMAN (1-309): 0: 529: 100.00		2AAA_HUMAN (674-930): 1.14e-10: 67.2: 17.97
+	Hs
		87320 PP2AA_HUMAN (1-309): 0: 529: 100.00		C9J9C1_HUMAN (686-930): 1.42e-10: 67.2: 18.38
+	Hs
		672072 PP2AB_HUMAN (1-309): 0: 528: 97.41		2AAA_HUMAN (674-930): 1.14e-10: 67.2: 17.97
+	Hs
		87319 PP2AB_HUMAN (1-309): 0: 528: 97.41		C9J9C1_HUMAN (686-930): 1.42e-10: 67.2: 18.38
+	Mm
		915332 PP2AB_MOUSE (1-309): 0: 528: 97.41		2AAA_MOUSE (674-930): 1.16e-10: 67.2: 17.97
+	Mm
		930638 PP2AA_MOUSE (1-309): 0: 528: 99.68		2AAA_MOUSE (674-930): 1.16e-10: 67.2: 17.97
+	Hs
		672402 PP2AA_HUMAN (1-309): 0: 529: 100.00		2AAB_HUMAN (67-715): 6e-10: 64.9: 13.40
+	Hs
		672399 PP2AB_HUMAN (1-309): 0: 528: 97.41		2AAB_HUMAN (67-715): 6e-10: 64.9: 13.40
+	Dm
		619857 PP2A_DROME (1-309): 0: 524: 93.85		2AAA_DROME (34-302): 8.08e-09: 61.4: 17.55
+	Hs
		890979 PP4C_HUMAN (4-309): 0: 508: 64.82		PP4R4_HUMAN (5-354): 8.54e-11: 68: 18.90
+	Mm
		956531 PP4C_MOUSE (4-309): 0: 508: 64.82		PP4R4_MOUSE (5-354): 1.17e-10: 67.6: 17.63
+	Hs
		672060 PP4C_HUMAN (4-309): 0: 508: 64.82		2AAA_HUMAN (674-930): 1.14e-10: 67.2: 17.97
+	Hs
		672395 PP4C_HUMAN (4-309): 0: 508: 64.82		2AAB_HUMAN (67-715): 6e-10: 64.9: 13.40