Protein: GAK
Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26)

Gene: GAK
Organism: Homo sapiens
Interactions: 179
UniProt ID: O14976

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

171717

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

4

16

Small-scale

0.914

High

171713

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

8

High-throughput

0.778

High

171775

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

1

High-throughput

0.726

High

171661

HSP7C
Heat shock cognate 71 kDa protein

4

7

Small-scale

0.699

High

171631

AXIN1
Axin-1

1

1

High-throughput

0.698

High

170460

RAB7L
Ras-related protein Rab-7L1

1

2

Small-scale

0.691

High

171638

DNJA2
DnaJ homolog subfamily A member 2

1

8

High-throughput

0.691

High

171639

AUXI
Auxilin

1

13

High-throughput

0.691

High

171650

LGI1
Leucine-rich glioma-inactivated protein 1

1

3

High-throughput

0.691

High

171664

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

18

High-throughput

0.691

High

171668

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.691

High

171682

IRAK1
Interleukin-1 receptor-associated kinase 1

1

6

High-throughput

0.691

High

171696

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.691

High

171698

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

20

High-throughput

0.691

High

171701

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

16

High-throughput

0.691

High

171702

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

15

High-throughput

0.691

High

171707

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.691

High

171712

AAK1
AP2-associated protein kinase 1

1

18

High-throughput

0.691

High

171736

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

4

High-throughput

0.691

High

171756

WNK3
Serine/threonine-protein kinase WNK3

1

17

High-throughput

0.691

High

171771

BMP2K
BMP-2-inducible protein kinase

1

16

High-throughput

0.691

High

171782

FEM1B
Protein fem-1 homolog B

1

5

High-throughput

0.691

High

171784

KDIS
Kinase D-interacting substrate of 220 kDa

1

4

High-throughput

0.691

High

171788

DAPP1
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide

1

19

High-throughput

0.691

High

171640

HIP1R
Huntingtin-interacting protein 1-related protein

3

13

High-throughput

0.675

High

171747

STALP
AMSH-like protease

3

3

High-throughput

0.675

High

171647

STABP
STAM-binding protein

3

3

High-throughput

0.667

High

171657

CLCA
Clathrin light chain A

3

10

High-throughput

0.667

High

171658

CLCB
Clathrin light chain B

3

10

High-throughput

0.667

High

171735

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.656

High

171752

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.656

High

171737

F174A
Membrane protein FAM174A

3

0

High-throughput

0.634

High

171675

CCNF
Cyclin-F

1

0

High-throughput

0.631

High

171710

INF2
Inverted formin-2

2

3

High-throughput

0.628

High

171733

PALS1
Protein PALS1

2

6

High-throughput

0.628

High

171770

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

3

High-throughput

0.628

High

171780

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

171793

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

8

High-throughput

0.619

High

171643

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.618

High

171656

SP1
Transcription factor Sp1

1

3

High-throughput

0.618

High

171671

CALL3
Calmodulin-like protein 3

1

14

High-throughput

0.618

High

171738

ACTT1
Actin-related protein T1

1

3

High-throughput

0.618

High

171748

PPM1M
Protein phosphatase 1M

1

19

High-throughput

0.618

High

171749

RBM14
RNA-binding protein 14

1

3

High-throughput

0.618

High

171753

RBM42
RNA-binding protein 42

1

4

High-throughput

0.618

High

171789

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.618

High

171652

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

171667

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.618

High

171689

ARP3
Actin-related protein 3

1

3

High-throughput

0.618

High

171693

CDK5
Cyclin-dependent kinase 5

1

7

Small-scale

0.618

High

171709

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

2

High-throughput

0.618

High

171742

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.618

High

171765

WNK1
Serine/threonine-protein kinase WNK1

1

19

High-throughput

0.618

High

171787

ALK
ALK tyrosine kinase receptor

1

16

Small-scale

0.618

High

171694

CLH1
Clathrin heavy chain 1

2

9

High-throughput

0.611

High

171697

DMWD
Dystrophia myotonica WD repeat-containing protein

3

9

High-throughput

0.609

High

171684

CCNG1
Cyclin-G1

1

0

Small-scale

0.606

High

171703

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.586

High

171769

AT132
Polyamine-transporting ATPase 13A2

1

8

Small-scale

0.582

High

171722

NIPA3
Magnesium transporter NIPA3

2

0

High-throughput

0.576

High

104004

F5GWT4
non-specific serine/threonine protein kinase

1

16

High-throughput

0.575

High

171628

GAK
Cyclin-G-associated kinase

1

18

Small-scale

0.575

High

171636

PRKY
Putative serine/threonine-protein kinase PRKY

1

17

High-throughput

0.575

High

171721

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.575

High

171731

CLASR
CLK4-associating serine/arginine rich protein

2

1

High-throughput

0.574

High

171773

HPBP1
Hsp70-binding protein 1

2

1

High-throughput

0.574

High

171785

CBLC
E3 ubiquitin-protein ligase CBL-C

2

1

High-throughput

0.574

High

171679

PAXI
Paxillin

2

9

High-throughput

0.571

High

171688

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

6

High-throughput

0.571

High

171725

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.553

High

171754

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.553

High

171766

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.553

High

171637

USO1
General vesicular transport factor p115

1

12

High-throughput

0.541

High

123505

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.536

High

130888

HIP1
Huntingtin-interacting protein 1

1

15

High-throughput

0.536

High

135846

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.536

High

171629

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

171645

AP2A2
AP-2 complex subunit alpha-2

1

18

High-throughput

0.536

High

171646

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

2

High-throughput

0.536

High

171648

AP2A1
AP-2 complex subunit alpha-1

1

18

High-throughput

0.536

High

171649

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

171651

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

2

High-throughput

0.536

High

171653

P53
Cellular tumor antigen p53

1

2

High-throughput

0.536

High

171659

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.536

High

171669

SAHH
Adenosylhomocysteinase

1

4

High-throughput

0.536

High

171670

S10A4
Protein S100-A4

1

7

High-throughput

0.536

High

171673

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.536

High

171676

EPS15
Epidermal growth factor receptor substrate 15

1

12

High-throughput

0.536

High

171677

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.536

High

171680

NUMB
Protein numb homolog

1

10

High-throughput

0.536

High

171681

MRE11
Double-strand break repair protein MRE11

1

1

High-throughput

0.536

High

171685

CLH2
Clathrin heavy chain 2

1

9

High-throughput

0.536

High

171686

SC24C
Protein transport protein Sec24C

1

2

High-throughput

0.536

High

171687

SEC13
Protein SEC13 homolog

1

7

High-throughput

0.536

High

171690

AP2B1
AP-2 complex subunit beta

1

18

High-throughput

0.536

High

171691

RACK1
Small ribosomal subunit protein RACK1

1

10

High-throughput

0.536

High

171692

DAB2
Disabled homolog 2

1

10

High-throughput

0.536

High

171699

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

14

High-throughput

0.536

High

171705

GOGB1
Golgin subfamily B member 1

1

18

High-throughput

0.536

High

171716

EFMT2
EEF1A lysine methyltransferase 2

1

2

High-throughput

0.536

High

171718

FA83B
Protein FAM83B

1

1

High-throughput

0.536

High

171719

CE162
Centrosomal protein of 162 kDa

1

17

High-throughput

0.536

High

171734

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

171739

DEN1A
DENN domain-containing protein 1A

1

2

High-throughput

0.536

High

171741

STON2
Stonin-2

1

7

High-throughput

0.536

High

171745

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

171746

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.536

High

171758

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

171764

ZN106
Zinc finger protein 106

1

14

High-throughput

0.536

High

171772

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.536

High

171778

LIMA1
LIM domain and actin-binding protein 1

1

7

High-throughput

0.536

High

171783

BAG5
BAG family molecular chaperone regulator 5

1

3

Small-scale

0.536

High

171786

MYO6
Unconventional myosin-VI

1

9

High-throughput

0.536

High

171792

KIF3A
Kinesin-like protein KIF3A

1

5

High-throughput

0.536

High

171633

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.513

High

171678

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

171729

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.513

High

171730

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

171755

CHM4A
Charged multivesicular body protein 4a

1

0

High-throughput

0.513

High

171767

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

171779

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

171655

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

171663

CBPM
Carboxypeptidase M

1

2

High-throughput

0.489

High

171683

PLXA3
Plexin-A3

1

4

High-throughput

0.489

High

171708

DREB
Drebrin

1

6

High-throughput

0.489

High

171724

FA83H
Protein FAM83H

1

1

High-throughput

0.489

High

171751

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.489

High

171762

PUS7L
Pseudouridylate synthase PUS7L

1

1

High-throughput

0.489

High

171768

PAAT
ATPase PAAT

1

3

High-throughput

0.489

High

171776

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.489

High

171634

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

171635

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

171641

PEX14
Peroxisomal membrane protein PEX14

1

1

High-throughput

0.479

High

171644

CBPD
Carboxypeptidase D

1

2

High-throughput

0.479

High

171654

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

171662

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

171700

CUL3
Cullin-3

1

10

High-throughput

0.479

High

171704

EPN4
Clathrin interactor 1

1

7

High-throughput

0.479

High

171706

CCDC6
Coiled-coil domain-containing protein 6

1

12

High-throughput

0.479

High

171711

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

171715

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

8

High-throughput

0.479

High

171723

SYNE3
Nesprin-3

1

17

High-throughput

0.479

High

171726

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

171728

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

171732

RHG18
Rho GTPase-activating protein 18

1

8

High-throughput

0.479

High

171740

SMAP2
Stromal membrane-associated protein 2

1

3

High-throughput

0.479

High

171743

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

171744

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

171757

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.479

High

171760

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.479

High

171761

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.479

High

171763

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

171777

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

171781

ANC2
Anaphase-promoting complex subunit 2

1

11

High-throughput

0.479

High

171794

HYOU1
Hypoxia up-regulated protein 1

1

12

High-throughput

0.479

High

171630

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.458

High

171642

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

171791

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

171660

ANDR
Androgen receptor

1

12

Small-scale

0.457

High

97019

E9PK67
Poly [ADP-ribose] polymerase

1

11

High-throughput

0.445

High

114511

H0YEF7
Phosphatidylinositol binding clathrin assembly protein

1

3

High-throughput

0.445

High

171695

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

1

High-throughput

0.445

High

171759

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

171790

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

104849

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

171665

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

171672

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

171674

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

171720

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

171727

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

171774

RN181
E3 ubiquitin-protein ligase RNF181

1

4

High-throughput

0.437

High

171666

KLK2
Kallikrein-2

1

4

High-throughput

0.407

High

171750

GPX7
Glutathione peroxidase 7

3

0

High-throughput

0.345

High

171632

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

171714

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

171795

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

139764

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

171796

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025