HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	32640226
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 833
+	Hs
		930913 PP2AA_HUMAN (1-309): 0: 529: 100.00		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		647866 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20
+	Hs
		915261 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK4_HUMAN (14-608): 3.78e-137: 426: 17.54
+	Hs
		930835 PP2AA_HUMAN (1-309): 0: 529: 100.00		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		915182 PP2AB_HUMAN (1-309): 0: 528: 97.41		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		681777 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		682162 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19
+	Mm
		682104 PP2AA_MOUSE (1-309): 0: 528: 99.68		AKT1_MOUSE (1-337): 5.84e-129: 396: 23.12
+	Hs
		931045 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT3_HUMAN (10-351): 5.23e-128: 394: 24.29
+	Ce
		108325 PP2A_CAEEL (3-309): 0: 519: 89.25		GCK1_CAEEL (12-448): 1.04e-118: 375: 31.77
+	Dm
		619909 PP2A_DROME (1-309): 0: 524: 93.85		Q9VEN3_DROME (10-325): 3.79e-116: 368: 39.12
+	Hs
		131564 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		131561 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		931026 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK26_HUMAN (1-396): 1.9e-116: 361: 33.84
+	Hs
		931059 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Hs
		915296 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK26_HUMAN (1-396): 1.9e-116: 361: 33.84
+	Hs
		915317 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Dm
		619891 PP2A_DROME (1-309): 0: 524: 93.85		HIPPO_DROME (13-289): 5.89e-110: 353: 43.17
+	Mm
		915321 PP2AB_MOUSE (1-309): 0: 528: 97.41		TNIK_MOUSE (11-296): 3.3e-64: 236: 42.57
+	Sc
		439624 PP2A1_YEAST (10-309): 0: 517: 76.00		SPS1_YEAST (13-274): 1.01e-59: 213: 43.40