HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: P2R3B (Q9Y5P8)
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (PP2A subunit B isoform PR48) (Protein phosphatase 2A 48 kDa regulatory subunit)
Gene: PPP2R3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.905

Property	Details
Experiments	27880917, 10629059, 18782753, 35271311
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	EF-hand_7~Metallophos
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0006470 - protein dephosphorylation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 575
+	Hs
		915316 PP2AB_HUMAN (1-309): 0: 528: 97.41		P2R3B_HUMAN (1-575): 0: 827: 100.00
+	Mm
		102664 PP2AA_MOUSE (1-309): 0: 528: 99.68		G3X9E8_MOUSE (77-535): 0: 622: 59.57
+	Hs
		930814 PP2AA_HUMAN (1-309): 0: 529: 100.00		P2R3A_HUMAN (119-535): 0: 609: 64.46
+	Hs
		930950 PP2AA_HUMAN (1-309): 0: 529: 100.00		P2R3C_HUMAN (104-501): 2.64e-128: 385: 19.76
+	Hs
		915251 PP2AB_HUMAN (1-309): 0: 528: 97.41		P2R3C_HUMAN (104-501): 2.64e-128: 385: 19.76
+	Ce
		108327 PP2A_CAEEL (3-309): 0: 519: 89.25		P2R31_CAEEL (112-485): 1.52e-62: 213: 17.35