Protein: HMCES
Abasic site processing protein HMCES (EC 4.-.-.-) (Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein) (ES cell-specific 5hmC-binding protein) (Peptidase HMCES) (EC 3.4.-.-) (SRAP domain-containing protein 1)

Gene: HMCES
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q96FZ2

Gene Ontology (top 5):
GO:0003697 - single-stranded DNA binding
GO:0005657 - replication fork
GO:0006508 - proteolysis
GO:0006974 - DNA damage response
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

589400

RFA2
Replication protein A 32 kDa subunit

4

1

High-throughput

0.691

High

1096785

RFA4
Replication protein A 30 kDa subunit

3

1

High-throughput

0.667

High

537702

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.604

High

768879

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.513

High

920188

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

1347611

NEIL3
Endonuclease 8-like 3

1

0

High-throughput

0.513

High

931057

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.489

High

1391120

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

861723

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.480

High

1349750

FBX25
F-box only protein 25

1

1

Small-scale

0.457

High

1380622

FBX32
F-box only protein 32

1

1

High-throughput

0.437

High

1006621

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.407

High

1391122

KLDC3
Kelch domain-containing protein 3

2

0

High-throughput

0.328

High

1391126

HPBP1
Hsp70-binding protein 1

2

0

High-throughput

0.328

High

422863

A4
Amyloid-beta precursor protein

2

0

High-throughput

0.314

High

219217

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.279

Low

256667

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.279

Low

347245

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

407684

S100B
Protein S100-B

1

0

High-throughput

0.279

Low

419130

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.279

Low

654127

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.279

Low

692777

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

946444

MTPN
Myotrophin

1

0

High-throughput

0.279

Low

998671

H31
Histone H3.1

1

0

High-throughput

0.279

Low

1048225

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.279

Low

1311954

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.279

Low

1391121

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.279

Low

1391124

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.279

Low

1391125

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.279

Low

1391128

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

0

High-throughput

0.279

Low

1391119

FAH2A
Oxaloacetate tautomerase FAHD2A, mitochondrial

1

0

High-throughput

0.269

Low

396699

ESR1
Estrogen receptor

1

0

High-throughput

0.249

Low

406496

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low

714348

PML
Protein PML

1

0

High-throughput

0.249

Low

1334766

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1387483

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.249

Low

1391127

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1337517

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.232

Low

1339809

TRI58
E3 ubiquitin-protein ligase TRIM58

1

0

High-throughput

0.232

Low

1352090

Q8TE30
RNA-directed DNA polymerase

1

0

Small-scale

0.232

Low

1391123

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025