HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: MYPC3 (Q14896)
Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
Gene: MYBPC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	1.00	0.730

Property	Details
Experiments	21569246, 23980194
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~I-set
Common GO terms	GO:0005829 - cytosol GO:0017022 - myosin binding GO:0030017 - sarcomere
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1274
+	Hs
		891771 ACTB_HUMAN (4-377): 0: 599: 94.12		MYPC3_HUMAN (1-1274): 0: 747: 100.00
+	Mm
		250929 ACTC_MOUSE (1-377): 0: 599: 100.00		MYPC3_MOUSE (1-1274): 0: 727: 87.52
+	Dm
		950123 ACT6_DROME (1-377): 0: 594: 92.84		TITIN_DROME (1109-1273): 4.41e-15: 83.4: 24.10
+	Hs
		255668 ACTC_HUMAN (1-377): 0: 599: 100.00		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Hs
		255670 ACTS_HUMAN (1-377): 0: 599: 98.94		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Dm
		54871 ACT6_DROME (1-377): 0: 594: 92.84		A1ZA72_DROME (1082-1274): 1.77e-11: 71.4: 16.50