HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: PHAR4 (Q8IZ21)
Phosphatase and actin regulator 4
Gene: PHACTR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	GO:0005737 - cytoplasm GO:0030027 - lamellipodium
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 702
+	Hs
		891891 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		929922 ACTG_HUMAN (4-377): 0: 599: 94.39		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		257134 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR2_HUMAN (9-702): 2.51e-39: 156: 35.81
+	Hs
		257139 ACTG_HUMAN (4-377): 0: 599: 94.39		PHAR2_HUMAN (9-702): 2.51e-39: 156: 35.81
+	Hs
		257140 ACTC_HUMAN (1-377): 0: 599: 100.00		PHAR2_HUMAN (9-702): 2.51e-39: 156: 35.81
+	Hs
		257136 ACTA_HUMAN (1-377): 0: 596: 98.41		PHAR2_HUMAN (9-702): 2.51e-39: 156: 35.81
+	Hs
		892113 ACTB_HUMAN (4-377): 0: 599: 94.12		MACF1_HUMAN (497-699): 3.78e-37: 152: 17.96
+	Hs
		891706 ACTB_HUMAN (4-377): 0: 599: 94.12		DYST_HUMAN (477-699): 6.74e-36: 148: 17.83
+	Hs
		932113 ACTC_HUMAN (1-377): 0: 599: 100.00		DYST_HUMAN (477-699): 6.74e-36: 148: 17.83
+	Hs
		3037 ACTB_HUMAN (4-377): 0: 599: 94.12		A0A0J9YVR0_HUMAN (1-204): 8.89e-39: 144: 95.76
+	Dm
		501561 ACT1_DROME (1-377): 0: 598: 94.43		Q9VZM9_DROME (15-702): 2.43e-35: 145: 25.37
+	Dm
		501562 ACT1_DROME (1-377): 0: 598: 94.43		Q9VZN2_DROME (137-702): 2.57e-30: 129: 25.18
+	Hs
		554290 ACTA_HUMAN (1-377): 0: 596: 98.41		MUC1_HUMAN (4-494): 4.09e-26: 117: 9.20
+	Hs
		933050 ACTS_HUMAN (1-377): 0: 599: 98.94		PHAR1_HUMAN (7-235): 1.63e-15: 82.4: 30.30
+	Hs
		932156 ACTC_HUMAN (1-377): 0: 599: 100.00		MDC1_HUMAN (61-694): 5.38e-15: 81.6: 10.31
+	Hs
		891978 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR3_HUMAN (3-264): 1.31e-14: 79.3: 24.81
+	Hs
		932331 ACTC_HUMAN (1-377): 0: 599: 100.00		PHAR3_HUMAN (3-264): 1.31e-14: 79.3: 24.81
+	Hs
		203220 ACTC_HUMAN (1-377): 0: 599: 100.00		SYNJ1_HUMAN (12-354): 5.61e-10: 65: 10.98