Protein: ORC4
Origin recognition complex subunit 4 (Origin recognition complex 56 kDa subunit)

Gene: ORC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 51
UniProt ID: P54791

Gene Ontology (top 5):
GO:0003688 - DNA replication origin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005656 - nuclear pre-replicative complex
GO:0005664 - nuclear origin of replication recognition complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932205

ORC1
Origin recognition complex subunit 1

17

15

Small-scale

0.986

High

898171

ORC5
Origin recognition complex subunit 5

11

13

Small-scale

0.980

High

745665

ORC2
Origin recognition complex subunit 2

11

13

Small-scale

0.975

High

932313

ORC3
Origin recognition complex subunit 3

8

2

Small-scale

0.964

High

479276

CDC6
Cell division control protein 6

5

16

Small-scale

0.912

High

713020

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.734

High

805522

ORC6
Origin recognition complex subunit 6

6

2

Small-scale

0.727

High

793890

PCH2
Pachytene checkpoint protein 2

1

1

Small-scale

0.647

High

721401

MCM4
DNA replication licensing factor MCM4

1

20

Small-scale

0.618

High

718956

CGS5
S-phase entry cyclin-5

2

9

Small-scale

0.611

High

381593

H2B2
Histone H2B.2

2

5

High-throughput

0.601

High

816146

HAT2
Histone acetyltransferase type B subunit 2

2

2

Small-scale

0.601

High

932331

HAT1
Histone acetyltransferase type B catalytic subunit

2

1

Small-scale

0.601

High

794092

MCM7
DNA replication licensing factor MCM7

1

19

Small-scale

0.575

High

823016

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.575

High

917045

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.575

High

381207

H2B1
Histone H2B.1

2

5

High-throughput

0.571

High

382272

H4
Histone H4

2

5

High-throughput

0.571

High

924982

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.552

High

819490

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

742165

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.536

High

665195

DPB2
DNA polymerase epsilon subunit B

1

1

High-throughput

0.515

High

932328

YRA1
RNA annealing protein YRA1

1

2

High-throughput

0.515

High

752597

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.514

High

735399

MCM10
Minichromosome maintenance protein 10

1

4

Small-scale

0.501

High

740608

IME2
Meiosis induction protein kinase IME2/SME1

1

13

Small-scale

0.501

High

865460

CDT1
Cell division cycle protein CDT1

1

2

Small-scale

0.501

High

808240

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

1

Small-scale

0.481

High

824975

CSM2
Chromosome segregation in meiosis protein 2

1

1

Small-scale

0.481

High

932329

PSY3
Platinum sensitivity protein 3

1

1

Small-scale

0.481

High

419834

H2A2
Histone H2A.2

1

3

High-throughput

0.479

High

707886

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

745837

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

763964

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

824991

FKH1
Fork head protein homolog 1

1

4

Small-scale

0.479

High

932323

ORC4
Origin recognition complex subunit 4

1

14

Small-scale

0.479

High

932325

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

932326

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

932327

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

792905

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.457

High

524826

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

527413

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

545886

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

736698

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.445

High

781779

SET3
SET domain-containing protein 3

1

2

High-throughput

0.445

High

932332

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.445

High

820430

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

932324

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

2

High-throughput

0.407

High

932330

HSP42
Heat shock protein 42

1

3

High-throughput

0.407

High

863687

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025