HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: PHAR3 (Q96KR7)
Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)
Gene: PHACTR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	28330616
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 559
+	Hs
		891978 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR3_HUMAN (1-559): 0: 646: 100.00
+	Hs
		933050 ACTS_HUMAN (1-377): 0: 599: 98.94		PHAR1_HUMAN (12-559): 0: 609: 42.45
+	Dm
		501562 ACT1_DROME (1-377): 0: 598: 94.43		Q9VZN2_DROME (375-559): 1.23e-75: 257: 52.97
+	Hs
		257134 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR2_HUMAN (40-260): 2.67e-59: 209: 27.43
+	Hs
		257139 ACTG_HUMAN (4-377): 0: 599: 94.39		PHAR2_HUMAN (40-260): 2.67e-59: 209: 27.43
+	Hs
		257140 ACTC_HUMAN (1-377): 0: 599: 100.00		PHAR2_HUMAN (40-260): 2.67e-59: 209: 27.43
+	Hs
		257136 ACTA_HUMAN (1-377): 0: 596: 98.41		PHAR2_HUMAN (40-260): 2.67e-59: 209: 27.43
+	Dm
		501561 ACT1_DROME (1-377): 0: 598: 94.43		Q9VZM9_DROME (46-239): 1.85e-41: 162: 26.34
+	Hs
		891891 ACTB_HUMAN (4-377): 0: 599: 94.12		PHAR4_HUMAN (34-246): 2.73e-35: 142: 26.03
+	Hs
		929922 ACTG_HUMAN (4-377): 0: 599: 94.39		PHAR4_HUMAN (34-246): 2.73e-35: 142: 26.03
+	Hs
		932253 ACTC_HUMAN (1-377): 0: 599: 100.00		PHAR4_HUMAN (34-246): 2.73e-35: 142: 26.03
+	Hs
		3037 ACTB_HUMAN (4-377): 0: 599: 94.12		A0A0J9YVR0_HUMAN (37-187): 3.16e-34: 130: 29.68