HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~HSA, Actin~SNF2-rel_dom
Common GO terms	GO:0005524 - ATP binding GO:0016787 - hydrolase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 3159
+	Hs
		891979 ACTB_HUMAN (4-377): 0: 599: 94.12		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		929972 ACTG_HUMAN (4-377): 0: 599: 94.39		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229358 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Dm
		501486 ACT1_DROME (1-377): 0: 598: 94.43		BRM_DROME (1527-2267): 3.24e-149: 512: 14.69
+	Dm
		361138 ACT2_DROME (1-377): 0: 596: 94.16		BRM_DROME (1527-2267): 3.24e-149: 512: 14.69
+	Hs
		892104 ACTB_HUMAN (4-377): 0: 599: 94.12		INO80_HUMAN (1754-2150): 2.56e-83: 307: 25.38
+	Sp
		144858 ACT_SCHPO (4-377): 0: 645: 89.04		INO80_SCHPO (1885-2049): 6.3e-22: 107: 35.54
+	Sp
		142452 ACT_SCHPO (4-377): 0: 645: 89.04		SWR1_SCHPO (1399-1518): 3.27e-15: 84.8: 9.17
+	Hs
		891853 ACTB_HUMAN (4-377): 0: 599: 94.12		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		929905 ACTG_HUMAN (4-377): 0: 599: 94.39		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		932219 ACTC_HUMAN (1-377): 0: 599: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Mm
		929800 ACTG_MOUSE (4-377): 0: 599: 94.39		EP400_MOUSE (2511-3159): 1.94e-10: 69.5: 10.79
+	Hs
		846742 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Mm
		929795 ACTG_MOUSE (4-377): 0: 599: 94.39		SMCA2_MOUSE (2682-2984): 5.95e-09: 64.5: 13.03
+	Mm
		929785 ACTG_MOUSE (4-377): 0: 599: 94.39		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		846910 ACTB_HUMAN (4-377): 0: 599: 94.12		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846917 ACTG_HUMAN (4-377): 0: 599: 94.39		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846918 ACTC_HUMAN (1-377): 0: 599: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Hs
		846919 ACTS_HUMAN (1-377): 0: 599: 98.94		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Xl
		292752 ACTB_XENLA (4-377): 0: 598: 94.12		Q4VQ79_XENLA (2756-3006): 7.42e-09: 64.1: 13.13