HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: TMOD3 (Q9NYL9)
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Gene: TMOD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	30890647, 28514442, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0007015 - actin filament organization
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 352
+	Hs
		892073 ACTB_HUMAN (4-377): 0: 599: 94.12		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		915520 ACTA_HUMAN (1-377): 0: 596: 98.41		TMOD3_HUMAN (1-352): 1.04e-142: 409: 100.00
+	Hs
		892077 ACTB_HUMAN (4-377): 0: 599: 94.12		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		930031 ACTG_HUMAN (4-377): 0: 599: 94.39		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		932417 ACTC_HUMAN (1-377): 0: 599: 100.00		TMOD2_HUMAN (1-352): 7.98e-135: 389: 75.85
+	Hs
		657477 ACTB_HUMAN (4-377): 0: 599: 94.12		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		657481 ACTG_HUMAN (4-377): 0: 599: 94.39		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		657479 ACTA_HUMAN (1-377): 0: 596: 98.41		TMOD1_HUMAN (3-348): 9.31e-129: 374: 62.14
+	Hs
		932227 ACTC_HUMAN (1-377): 0: 599: 100.00		NLRC3_HUMAN (189-312): 3.36e-23: 102: 22.58
+	Hs
		886390 ACTB_HUMAN (4-377): 0: 599: 94.12		NAL12_HUMAN (188-282): 6.81e-11: 65.5: 18.75