HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCN5A (Q9JJV9)
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (mH1)
Gene: SCN5A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.50	0.590

Property	Details
Experiments	15123669, 32175648, 34086898
Identification Methods	far western blotting, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 2019
+	Hs
		1055040 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Hs
		808128 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Mm
		69865 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (3-2003): 0: 1872: 61.18
+	Mm
		93276 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNAA_MOUSE (5-2014): 0: 1842: 60.96
+	Mm
		93274 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (2-2006): 0: 1839: 60.31
+	Mm
		93284 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN8A_MOUSE (2-2003): 0: 1745: 59.81
+	Hs
		723839 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN1A_HUMAN (4-2003): 0: 1820: 60.57
+	Hs
		808340 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNAA_HUMAN (5-2007): 0: 1780: 61.77
+	Hs
		808322 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN8A_HUMAN (2-2003): 0: 1739: 59.51
+	Hs
		1055045 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Hs
		125457 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCN5A_HUMAN (1-2019): 0: 2031: 94.30
+	Mm
		69867 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN2A_MOUSE (3-2003): 0: 1872: 61.18
+	Hs
		1079738 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN9A_HUMAN (2-2005): 0: 1834: 59.87
+	Mm
		808358 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN9A_MOUSE (2-2006): 0: 1839: 60.31
+	Hs
		723851 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN1A_HUMAN (4-2003): 0: 1820: 60.57
+	Mm
		93270 E9PXB7_MOUSE (1-835): 0: 959: 100.00		Q3UF73_MOUSE (4-204): 2.88e-86: 282: 68.66
+	Hs
		1047217 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (21-553): 3.82e-23: 110: 15.79
+	Mm
		808349 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		Q3UF73_MOUSE (4-204): 2.88e-86: 282: 68.66
+	Hs
		132322 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		CAC1A_HUMAN (706-1044): 9.89e-36: 151: 19.00
+	Hs
		125445 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		CAC1C_HUMAN (21-553): 3.82e-23: 110: 15.79