HitPredict

Interactor 1: E9PXB7 (E9PXB7)
E3 ubiquitin-protein ligase (EC 2.3.2.26)
Gene: Nedd4l

Interactor 2: SCN8A (Q9WTU3)
Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Gene: SCN8A

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	15123669
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 835 Mm			1 1978
+	Mm
		69865 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN2A_MOUSE (1-1977): 0: 1971: 72.90
+	Hs
		808322 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN8A_HUMAN (1-1978): 0: 2045: 98.23
+	Mm
		93274 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN9A_MOUSE (4-1972): 0: 1915: 68.43
+	Hs
		1055040 NED4L_HUMAN (1-835): 0: 944: 95.79		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		723839 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN1A_HUMAN (1-1966): 0: 1908: 72.98
+	Mm
		93276 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCNAA_MOUSE (6-1975): 0: 1785: 53.16
+	Hs
		808128 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		808340 NEDD4_HUMAN (1-835): 0: 845: 60.41		SCNAA_HUMAN (6-1973): 0: 1738: 53.71
+	Mm
		69867 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN2A_MOUSE (1-1977): 0: 1971: 72.90
+	Hs
		1079738 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN9A_HUMAN (4-1977): 0: 1924: 69.41
+	Hs
		723851 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN1A_HUMAN (1-1966): 0: 1908: 72.98
+	Mm
		808358 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		SCN9A_MOUSE (4-1972): 0: 1915: 68.43
+	Hs
		1055045 SMUF2_HUMAN (11-105): 1.77e-21: 102: 26.85		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Hs
		125457 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		SCN5A_HUMAN (3-1939): 0: 1815: 61.44
+	Mm
		93270 E9PXB7_MOUSE (1-835): 0: 959: 100.00		Q3UF73_MOUSE (1-205): 2.02e-95: 308: 72.68
+	Mm
		93283 E9PXB7_MOUSE (1-835): 0: 959: 100.00		SCN5A_MOUSE (343-654): 1.19e-13: 79.2: 11.98
+	Hs
		1047217 NED4L_HUMAN (1-835): 0: 944: 95.79		CAC1C_HUMAN (20-336): 1.49e-15: 85.3: 16.32
+	Mm
		808349 NEDD4_MOUSE (10-135): 2.3e-17: 89.1: 16.67		Q3UF73_MOUSE (1-205): 2.02e-95: 308: 72.68
+	Hs
		125445 WWP2_HUMAN (24-172): 1.78e-20: 99.1: 20.00		CAC1C_HUMAN (20-336): 1.49e-15: 85.3: 16.32
+	Hs
		132322 HECW1_HUMAN (153-500): 2.68e-18: 92.6: 16.54		CAC1A_HUMAN (351-669): 2.38e-16: 88: 13.82