Protein: CYFP1
Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1)

Gene: CYFP1, Cyfip1
Organism: Mus musculus
Interactions: 133
UniProt ID: Q7TMB8

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0005522 - profilin binding
GO:0008360 - regulation of cell shape
GO:0010592 - positive regulation of lamellipodium assembly
GO:0016601 - Rac protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1190156

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

2

1

High-throughput

0.811

High

1274204

WASF1
Actin-binding protein WASF1

2

13

Small-scale

0.811

High

1210178

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

1

High-throughput

0.789

High

704288

NCKP1
Nck-associated protein 1

1

6

High-throughput

0.691

High

988894

RAC1
Ras-related C3 botulinum toxin substrate 1

1

17

High-throughput

0.691

High

1274195

ABI1
Abl interactor 1

1

11

High-throughput

0.691

High

1223832

RHOC
Rho-related GTP-binding protein RhoC

1

15

High-throughput

0.618

High

1193789

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

7

High-throughput

0.611

High

1223579

DLG4
Disks large homolog 4

2

3

High-throughput

0.611

High

1274209

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.578

High

104566

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

2

High-throughput

0.574

High

1274188

NYAP2
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

2

9

Small-scale

0.574

High

1274215

DLGP1
Disks large-associated protein 1

2

2

High-throughput

0.558

High

686976

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

Small-scale

0.554

High

92681

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

5

High-throughput

0.536

High

107107

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

4

High-throughput

0.536

High

236980

CNTP1
Contactin-associated protein 1

1

1

High-throughput

0.536

High

470777

NFL
Neurofilament light polypeptide

1

3

High-throughput

0.536

High

470803

NFM
Neurofilament medium polypeptide

1

4

High-throughput

0.536

High

581995

NTRK2
BDNF/NT-3 growth factors receptor

1

7

High-throughput

0.536

High

591059

KPCE
Protein kinase C epsilon type

1

2

High-throughput

0.536

High

771426

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

1

High-throughput

0.536

High

810549

DYN2
Dynamin-2

1

5

High-throughput

0.536

High

953260

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.536

High

958844

ARF3
ADP-ribosylation factor 3

1

2

High-throughput

0.536

High

989515

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.536

High

993938

KPCG
Protein kinase C gamma type

1

3

High-throughput

0.536

High

1013630

TNIK
Traf2 and NCK-interacting protein kinase

1

3

High-throughput

0.536

High

1021379

DPYL1
Dihydropyrimidinase-related protein 1

1

3

High-throughput

0.536

High

1043831

KCNB1
Potassium voltage-gated channel subfamily B member 1

1

1

High-throughput

0.536

High

1190247

AAK1
AP2-associated protein kinase 1

1

2

High-throughput

0.536

High

1221929

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

High-throughput

0.536

High

1273329

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

2

High-throughput

0.536

High

1274187

BAIP2
BAR/IMD domain-containing adapter protein 2

1

5

High-throughput

0.536

High

1274189

KS6B1
Ribosomal protein S6 kinase beta-1

1

3

High-throughput

0.536

High

1274194

ANK2
Ankyrin-2

1

1

High-throughput

0.536

High

1274201

DNM1L
Dynamin-1-like protein

1

5

High-throughput

0.536

High

1274211

MYO5A
Unconventional myosin-Va

1

1

High-throughput

0.536

High

1274217

TSC1
Hamartin

1

1

High-throughput

0.536

High

1274220

DCLK1
Serine/threonine-protein kinase DCLK1

1

9

High-throughput

0.536

High

1274221

CUL3
Cullin-3

1

2

High-throughput

0.536

High

1274224

DREB
Drebrin

1

4

High-throughput

0.536

High

1274232

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.536

High

148304

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.513

High

313376

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

0

High-throughput

0.513

High

948499

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

961460

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.513

High

1253330

MTMR5
Myotubularin-related protein 5

1

0

High-throughput

0.513

High

1274197

RPGF2
Rap guanine nucleotide exchange factor 2

1

0

High-throughput

0.513

High

1274198

S4A8
Electroneutral sodium bicarbonate exchanger 1

1

0

High-throughput

0.513

High

1274206

IPO4
Importin-4

1

0

High-throughput

0.513

High

1274210

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.513

High

1274214

TPD54
Tumor protein D54

1

0

High-throughput

0.513

High

1274226

GRM3
Metabotropic glutamate receptor 3

1

0

High-throughput

0.513

High

1274228

DEST
Destrin

1

0

High-throughput

0.513

High

1274231

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.513

High

1274233

NCDN
Neurochondrin

1

0

High-throughput

0.513

High

1274234

P2RX7
P2X purinoceptor 7

1

0

High-throughput

0.513

High

147526

DPYL2
Dihydropyrimidinase-related protein 2

1

3

High-throughput

0.489

High

204507

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

2

High-throughput

0.489

High

205321

AP1B1
AP-1 complex subunit beta-1

1

3

High-throughput

0.489

High

548959

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

5

High-throughput

0.489

High

604463

AP2A1
AP-2 complex subunit alpha-1

1

3

High-throughput

0.489

High

619285

NFH
Neurofilament heavy polypeptide

1

4

High-throughput

0.489

High

704223

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

5

High-throughput

0.489

High

704834

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.489

High

810530

DYN1
Dynamin-1

1

5

High-throughput

0.489

High

857226

NSF
Vesicle-fusing ATPase

1

1

High-throughput

0.489

High

945996

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

5

High-throughput

0.489

High

989695

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.489

High

998182

KPCB
Protein kinase C beta type

1

3

High-throughput

0.489

High

1190269

CAMKV
CaM kinase-like vesicle-associated protein

1

7

High-throughput

0.489

High

1222995

AP180
Clathrin coat assembly protein AP180

1

2

High-throughput

0.489

High

1223939

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

9

High-throughput

0.489

High

1229317

Q68FG2
Spectrin beta chain

1

8

High-throughput

0.489

High

1274184

MFN2
Mitofusin-2

1

1

High-throughput

0.489

High

1274191

DYN3
Dynamin-3

1

5

High-throughput

0.489

High

1274205

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

2

High-throughput

0.489

High

1274207

DLG2
Disks large homolog 2

1

3

High-throughput

0.489

High

1274212

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.489

High

1274216

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.489

High

1274222

TRPC4
Short transient receptor potential channel 4

1

1

High-throughput

0.489

High

1274235

E41L1
Band 4.1-like protein 1

1

4

High-throughput

0.489

High

109233

G5E884
non-specific serine/threonine protein kinase

1

2

High-throughput

0.479

High

266787

LNX1
E3 ubiquitin-protein ligase LNX

1

3

High-throughput

0.479

High

1247091

NEB2
Neurabin-2

1

5

High-throughput

0.479

High

1274185

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.479

High

1274219

PROF2
Profilin-2

1

1

Small-scale

0.479

High

1188341

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

312744

PAK1
Serine/threonine-protein kinase PAK 1

1

1

High-throughput

0.445

High

777938

FMR1
Fragile X messenger ribonucleoprotein 1

1

9

Small-scale

0.445

High

1204107

MYO16
Unconventional myosin-XVI

1

5

Small-scale

0.445

High

1274225

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4

1

9

High-throughput

0.445

High

86352

B9EKJ1
Spectrin alpha chain, non-erythrocytic 1

1

9

High-throughput

0.437

High

98223

E9Q803
YLP motif-containing protein 1

1

4

High-throughput

0.437

High

1189518

Q3TMU8
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.437

High

1190801

Q3URF1
Synaptopodin

1

2

High-throughput

0.437

High

1274208

EED
Polycomb protein EED

1

1

High-throughput

0.437

High

1274223

CAF1A
Chromatin assembly factor 1 subunit A

1

3

High-throughput

0.437

High

204215

DPYL4
Dihydropyrimidinase-related protein 4

1

3

High-throughput

0.407

High

597656

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

High-throughput

0.407

High

1274182

Q80TE2
MKIAA1400 protein

1

1

Small-scale

0.407

High

1274196

SYNPO
Synaptopodin

1

2

High-throughput

0.407

High

1274213

NPS3B
Protein NipSnap homolog 3B

1

1

High-throughput

0.407

High

1274227

YLPM1
YLP motif-containing protein 1

1

3

High-throughput

0.407

High

74216

TM240
Transmembrane protein 240

1

0

High-throughput

0.279

Low

148515

NUMBL
Numb-like protein

1

0

High-throughput

0.279

Low

237004

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.279

Low

578753

GLNA
Glutamine synthetase

1

0

High-throughput

0.279

Low

665764

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.279

Low

866600

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

873139

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.279

Low

934318

NCAN
Neurocan core protein

1

0

High-throughput

0.279

Low

965430

AP1S1
AP-1 complex subunit sigma-1A

1

0

High-throughput

0.279

Low

976966

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.279

Low

1009998

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.279

Low

1083957

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.279

Low

1179051

PHAR1
Phosphatase and actin regulator 1

1

0

High-throughput

0.279

Low

1244426

ERC2
ERC protein 2

1

0

High-throughput

0.279

Low

1253340

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O

1

0

High-throughput

0.279

Low

1274183

AUXI
Auxilin

1

0

High-throughput

0.279

Low

1274186

LRC24
Leucine-rich repeat-containing protein 24

1

0

High-throughput

0.279

Low

1274190

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.279

Low

1274192

PPCEL
Prolyl endopeptidase-like

1

0

High-throughput

0.279

Low

1274193

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.279

Low

1274199

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

1274200

URP2
Fermitin family homolog 3

1

0

High-throughput

0.279

Low

1274202

MATR3
Matrin-3

1

0

High-throughput

0.279

Low

1274203

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.279

Low

1274218

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.279

Low

1274229

TRIM3
Tripartite motif-containing protein 3

1

0

High-throughput

0.279

Low

1274230

PDC6I
Programmed cell death 6-interacting protein

1

0

High-throughput

0.279

Low

97912

PI4KA
Phosphatidylinositol 4-kinase alpha

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025