HitPredict

Interactor 1: E9PYG6 (E9PYG6)
RAS p21 protein activator 1
Gene: Rasa1

Interactor 2: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	20697350, 9221755, 10567556, 9620604
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Mm			1 482
+	Rn
		842411 RASA1_RAT (1-1038): 0: 801: 98.65		DOK1_RAT (1-482): 0: 541: 93.78
+	Hs
		596429 RASA1_HUMAN (1-1038): 0: 782: 94.17		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Mm
		93301 E9PYG6_MOUSE (1-1038): 0: 812: 100.00		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Hs
		235043 RASA1_HUMAN (1-1038): 0: 782: 94.17		DOK2_HUMAN (2-425): 5.48e-106: 323: 34.16
+	Hs
		986022 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Mm
		956523 Q91YX7_MOUSE (103-289): 1.77e-16: 86.7: 18.00		DOK1_MOUSE (1-482): 0: 545: 100.00
+	Mm
		250956 Q91YX7_MOUSE (103-289): 1.77e-16: 86.7: 18.00		DOK2_MOUSE (2-425): 3.71e-101: 311: 33.11
+	Hs
		151763 GRB2_HUMAN (172-308): 8.6e-11: 64.7: 30.71		IRS4_HUMAN (6-406): 7.52e-92: 305: 14.29
+	Rn
		94387 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		F1MAL5_RAT (6-370): 1.89e-72: 251: 13.82
+	Hs
		985997 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		FRS2_HUMAN (135-478): 2.91e-75: 247: 20.31
+	Rn
		724630 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		IRS1_RAT (6-365): 6.72e-71: 246: 16.27
+	Hs
		986064 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		IRS2_HUMAN (6-368): 7.77e-71: 246: 12.78
+	Rn
		88883 PTN11_RAT (159-338): 5.59e-25: 113: 24.63		D4A244_RAT (135-478): 2.2e-72: 239: 19.79
+	Mm
		719314 PTN11_MOUSE (159-338): 5.59e-25: 113: 24.63		FRS2_MOUSE (135-478): 4.6e-72: 238: 19.54
+	Hs
		724535 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		IRS1_HUMAN (6-360): 6.38e-68: 237: 16.01
+	Hs
		207310 PTN11_HUMAN (159-338): 5.59e-25: 113: 24.63		FRS3_HUMAN (135-480): 5.71e-67: 224: 19.11
+	Rn
		94388 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		F1MAL5_RAT (6-370): 1.89e-72: 251: 13.82
+	Rn
		724631 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		IRS1_RAT (6-365): 6.72e-71: 246: 16.27
+	Rn
		88884 GRB2_RAT (172-308): 8.6e-11: 64.7: 30.71		D4A244_RAT (135-478): 2.2e-72: 239: 19.79
+	Hs
		724527 GRB2_HUMAN (172-308): 8.6e-11: 64.7: 30.71		IRS1_HUMAN (6-360): 6.38e-68: 237: 16.01