HitPredict

Interactor 1: 1433T (P68254)
14-3-3 protein theta (14-3-3 protein tau)
Gene: Ywhaq

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	20659021, 21390248, 20642453, unassigned1853
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0044325 - transmembrane transporter binding GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Mm			1 2527
+	Mm
		910249 1433E_MOUSE (2-243): 9.76e-145: 406: 63.93		LRRK2_MOUSE (1-2527): 0: 2800: 100.00
+	Mm
		926794 1433Z_MOUSE (1-245): 1.97e-142: 400: 79.59		LRRK2_MOUSE (1-2527): 0: 2800: 100.00
+	Hs
		909643 1433E_HUMAN (2-243): 9.76e-145: 406: 63.93		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	Hs
		927126 1433Z_HUMAN (1-245): 1.19e-141: 398: 79.18		LRRK2_HUMAN (1-2527): 0: 2770: 86.60
+	At
		788442 14331_ARATH (3-242): 1.99e-142: 401: 61.48		EMS1_ARATH (796-1502): 3.2e-130: 444: 17.01
+	At
		788640 14333_ARATH (3-243): 6.02e-143: 401: 62.04		EMS1_ARATH (796-1502): 3.2e-130: 444: 17.01
+	At
		186958 14332_ARATH (3-243): 6.29e-144: 404: 61.63		BRI1_ARATH (872-1542): 2.79e-107: 376: 17.55
+	At
		965327 14332_ARATH (3-243): 6.29e-144: 404: 61.63		PBS1_ARATH (1881-2133): 4.81e-84: 286: 28.83
+	At
		965375 14332_ARATH (3-243): 6.29e-144: 404: 61.63		BRL2_ARATH (1163-1691): 8.18e-42: 171: 11.98
+	At
		788683 14333_ARATH (3-243): 6.02e-143: 401: 62.04		BRL2_ARATH (1163-1691): 8.18e-42: 171: 11.98
+	Hs
		201290 1433E_HUMAN (2-243): 9.76e-145: 406: 63.93		M3K7_HUMAN (1869-2143): 1.77e-23: 110: 30.14
+	Hs
		909438 1433E_HUMAN (2-243): 9.76e-145: 406: 63.93		M3K9_HUMAN (1874-2136): 2.58e-23: 110: 32.39
+	Hs
		909462 1433E_HUMAN (2-243): 9.76e-145: 406: 63.93		M3K10_HUMAN (1864-2136): 2.53e-22: 107: 32.54
+	Hs
		788960 1433E_HUMAN (2-243): 9.76e-145: 406: 63.93		MATK_HUMAN (1885-2123): 2.28e-22: 105: 30.71
+	Hs
		646793 1433T_HUMAN (1-245): 7.86e-142: 398: 99.59		M3K9_HUMAN (1874-2136): 2.58e-23: 110: 32.39
+	Hs
		926918 1433Z_HUMAN (1-245): 1.19e-141: 398: 79.18		M3K9_HUMAN (1874-2136): 2.58e-23: 110: 32.39
+	Hs
		646816 1433T_HUMAN (1-245): 7.86e-142: 398: 99.59		M3K10_HUMAN (1864-2136): 2.53e-22: 107: 32.54
+	Hs
		926946 1433Z_HUMAN (1-245): 1.19e-141: 398: 79.18		M3K10_HUMAN (1864-2136): 2.53e-22: 107: 32.54
+	Zm
		22560 B6U284_MAIZE (1-243): 1.75e-143: 403: 60.32		A0A1D6I257_MAIZE (592-924): 4.36e-14: 80.8: 13.27
+	At
		965369 14332_ARATH (3-243): 6.29e-144: 404: 61.63		CLV1_ARATH (612-837): 4.62e-13: 77.4: 10.55