HitPredict

Interactor 1: CSK21 (P68400)
Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1)
Gene: CSNK2A1

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	19680552, 34163012, 20439735, 19236849, 21968188
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, in-gel kinase assay
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0008284 - positive regulation of cell population proliferation and 1 others more... GO:0016605 - PML body
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 391 Hs			1 747
+	Hs
		625550 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		586914 CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08		SIR1_HUMAN (1-747): 0: 1052: 100.00
+	Hs
		625510 CDK2_HUMAN (36-330): 5.34e-122: 356: 29.74		SIR2_HUMAN (210-559): 8.78e-120: 366: 34.13
+	Sc
		416191 CSK22_YEAST (2-326): 1.7e-120: 354: 59.51		SIR2_YEAST (222-513): 2.16e-103: 330: 38.04
+	Hs
		934506 CSK21_HUMAN (1-391): 2.89e-136: 396: 100.00		SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15
+	Sc
		416189 CSK21_YEAST (1-329): 6.88e-113: 336: 54.32		SIR2_YEAST (222-513): 2.16e-103: 330: 38.04
+	Hs
		586856 CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08		SIR6_HUMAN (230-546): 7.12e-92: 292: 21.77
+	Hs
		587007 CSK22_HUMAN (1-334): 4.14e-119: 351: 85.08		SIR7_HUMAN (179-541): 2.86e-87: 282: 19.15