HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: HDAC8 (Q9BY41)
Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-)
Gene: HDAC8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10926844
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 377
+	Hs
		934735 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	Hs
		1038423 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	Hs
		952319 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	Hs
		111560 K7EK07_HUMAN (1-132): 2.4e-59: 181: 96.21		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	Hs
		935063 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC2_HUMAN (11-376): 3.92e-180: 511: 40.60
+	Hs
		1086250 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC2_HUMAN (11-376): 3.92e-180: 511: 40.60
+	Hs
		952512 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC2_HUMAN (11-376): 3.92e-180: 511: 40.60
+	Hs
		828220 CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00		HDAC1_HUMAN (6-376): 0: 539: 39.79
+	At
		886469 H33_ARATH (1-136): 7.67e-62: 187: 96.32		HDA6_ARATH (1-377): 9.96e-175: 496: 40.53
+	Hs
		177255 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC3_HUMAN (12-376): 1.22e-173: 492: 40.60
+	Sc
		693050 H3_YEAST (1-136): 1.16e-55: 172: 88.97		RPD3_YEAST (7-375): 1.14e-179: 507: 40.27
+	Mm
		952773 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		Q9JM08_MOUSE (12-376): 1.39e-171: 486: 40.05
+	Hs
		1086303 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC8_HUMAN (1-377): 8.25e-168: 475: 100.00
+	Sp
		140575 H31_SCHPO (1-136): 3.54e-59: 181: 91.91		PHD1_SCHPO (11-376): 6.03e-165: 470: 34.96
+	Ce
		184839 HCP3_CAEEL (11-131): 9.69e-45: 149: 48.39		HDA1_CAEEL (11-376): 3.07e-175: 497: 39.78
+	Sc
		859059 H3_YEAST (1-136): 1.16e-55: 172: 88.97		HOS2_YEAST (13-376): 1.35e-157: 452: 36.41
+	Sc
		866875 H3_YEAST (1-136): 1.16e-55: 172: 88.97		HDA1_YEAST (6-333): 5.27e-130: 390: 23.66
+	Hs
		935331 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC6_HUMAN (1-328): 2.59e-94: 307: 24.78