HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: SETD2 (Q9BYW2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Gene: SETD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.738

Property	Details
Experiments	27528607, 16118227
Identification Methods	unspecified method, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 2564
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (1-2564): 0: 3956: 100.00
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (1370-1689): 2.66e-92: 308: 23.66
+	Hs
		203664 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		SUV91_HUMAN (1370-1689): 2.66e-92: 308: 23.66
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		935205 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		1086307 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		935129 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		1086280 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		935251 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38
+	Hs
		1086320 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (1334-1793): 2.85e-70: 266: 25.90
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (1420-1689): 3.06e-77: 265: 23.13
+	Hs
		935126 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT2_HUMAN (1443-1686): 2.36e-66: 250: 25.28
+	Hs
		1086279 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT2_HUMAN (1443-1686): 2.36e-66: 250: 25.28
+	Mm
		952777 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		EHMT2_MOUSE (1443-1686): 6.26e-66: 249: 25.28
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Mm
		952747 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		EZH2_MOUSE (1539-1670): 3.93e-17: 90.5: 36.36
+	Mm
		952754 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		Q6AXH7_MOUSE (1539-1670): 3.81e-17: 90.5: 36.36