HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	24722339, 35676659
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1215
+	Hs
		934735 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		1038423 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		952319 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		111560 K7EK07_HUMAN (1-132): 2.4e-59: 181: 96.21		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		935063 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		1086250 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		952512 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Mm
		952741 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		Q3UJF1_MOUSE (15-472): 3.03e-147: 474: 30.97
+	Hs
		935381 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		1086354 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		952704 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		177255 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Sc
		866875 H3_YEAST (1-136): 1.16e-55: 172: 88.97		HDA1_YEAST (80-456): 4.66e-148: 464: 33.17
+	Sc
		693050 H3_YEAST (1-136): 1.16e-55: 172: 88.97		RPD3_YEAST (75-473): 1.1e-149: 458: 20.24
+	Hs
		952692 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		HDAC9_HUMAN (7-432): 5.62e-136: 441: 33.19
+	Hs
		1174685 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		HDAC9_HUMAN (7-432): 5.62e-136: 441: 33.19
+	Ce
		184839 HCP3_CAEEL (11-131): 9.69e-45: 149: 48.39		HDA1_CAEEL (478-901): 1.62e-150: 461: 18.82
+	Mm
		952773 H33_MOUSE (1-136): 2.73e-61: 186: 96.32		Q9JM08_MOUSE (477-890): 2.06e-134: 418: 19.31
+	Hs
		935199 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		HDAC8_HUMAN (103-388): 4.42e-19: 92.8: 26.67
+	Hs
		1086303 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		HDAC8_HUMAN (103-388): 4.42e-19: 92.8: 26.67