HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	26527279, 29568061, 36089195, 34349018
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 136 Hs			1 1217
+	Hs
		952703 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1174693 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Sc
		810766 H3_YEAST (1-136): 1.16e-55: 172: 88.97		SMC3_YEAST (1-1217): 1.81e-84: 302: 29.80
+	Hs
		934764 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		952339 H33_HUMAN (1-136): 2.73e-61: 186: 96.32		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311570 H32_HUMAN (1-136): 6.5e-61: 185: 99.27		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Sc
		758751 H3_YEAST (1-136): 1.16e-55: 172: 88.97		SMC2_YEAST (1-1201): 8.11e-75: 273: 19.41
+	Sc
		730847 CENPA_YEAST (18-134): 2.12e-41: 138: 55.83		SMC3_YEAST (1-1217): 1.81e-84: 302: 29.80