Protein: IOD3
Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase)

Gene: IOD3, DIO3
Organism: Homo sapiens
Interactions: 20
UniProt ID: P55073

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004800 - thyroxine 5'-deiodinase activity
GO:0005886 - plasma membrane
GO:0010008 - endosome membrane
GO:0033798 - thyroxine 5-deiodinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935381

CNNM4
Metal transporter CNNM4

1

1

High-throughput

0.536

High

935383

CNNM2
Metal transporter CNNM2

1

1

High-throughput

0.536

High

180499

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.513

High

184418

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.513

High

565589

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.513

High

935378

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.513

High

935382

AN13A
Ankyrin repeat domain-containing protein 13A

1

0

High-throughput

0.513

High

935388

S12A7
Solute carrier family 12 member 7

1

0

High-throughput

0.513

High

49090

BLT3B
Bridge-like lipid transfer protein family member 3B

1

1

High-throughput

0.489

High

935380

BLT3A
Bridge-like lipid transfer protein family member 3A

1

1

High-throughput

0.489

High

935386

AT131
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.489

High

421793

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

935387

ANM7
Protein arginine N-methyltransferase 7

1

1

Small-scale

0.457

High

923409

SC5A3
Sodium/myo-inositol cotransporter

1

0

High-throughput

0.426

High

60498

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

1

0

High-throughput

0.279

Low

773837

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

935379

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

0

High-throughput

0.279

Low

935385

XPO5
Exportin-5

1

0

High-throughput

0.279

Low

162518

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.261

Low

935384

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025