Interactor 1: HES5 (P70120)
Transcription factor HES-5 (Hairy and enhancer of split 5)
Gene: HES5

Interactor 2: HELT (Q7TS99)
Hairy and enhancer of split-related protein HELT (HES/HEY-like transcription factor) (Protein Hes-like) (Protein megane)
Gene: HELT

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 14764602
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Hairy_orange~Hairy_orange, HLH~HLH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0005634 - nucleus
and 5 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 167
Mm

1 240
+ Hs
+ Hs
+ Gg
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Gg
+ Dm
+ Hs
+ Dm
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024