HitPredict

Interactor 1: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Interactor 2: BAG6 (Q9Z1R2)
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein Scythe)
Gene: BAG6

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	27501752, 15102471
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042981 - regulation of apoptotic process
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 530 Mm			1 1154
+	Hs
		803694 TRI11_HUMAN (56-412): 3.16e-46: 169: 12.74		BAG6_HUMAN (1-1154): 8.21e-153: 488: 86.83
+	Hs
		803535 TRI25_HUMAN (63-387): 4.89e-43: 164: 13.39		BAG6_HUMAN (1-1154): 8.21e-153: 488: 86.83
+	Hs
		584896 RO52_HUMAN (56-417): 1.99e-43: 162: 12.88		BAG6_HUMAN (1-1154): 8.21e-153: 488: 86.83
+	Hs
		536755 TRI27_HUMAN (56-385): 9.43e-39: 150: 11.87		BAG6_HUMAN (1-1154): 8.21e-153: 488: 86.83
+	Hs
		1224165 TRAF6_HUMAN (1-530): 1.18e-143: 425: 87.93		KMT2E_HUMAN (27-574): 5.37e-09: 62.9: 9.45
+	Mm
		101444 TRAF3_MOUSE (14-510): 9.77e-92: 293: 21.64		F8VPR5_MOUSE (8-841): 8.91e-11: 68.7: 8.46
+	Mm
		1141408 TRAF3_MOUSE (14-510): 9.77e-92: 293: 21.64		ASPP1_MOUSE (392-720): 4.85e-09: 62.9: 19.48
+	Hs
		301757 TRI37_HUMAN (56-519): 8.78e-49: 183: 14.83		MAP1A_HUMAN (189-793): 1.65e-21: 104: 11.24
+	Hs
		537122 TRI27_HUMAN (56-385): 9.43e-39: 150: 11.87		MAGL2_HUMAN (3-760): 5.11e-21: 102: 9.58
+	Hs
		301858 TRI37_HUMAN (56-519): 8.78e-49: 183: 14.83		SNPC4_HUMAN (98-772): 1.19e-09: 65.1: 14.72
+	Hs
		1052706 TRI25_HUMAN (63-387): 4.89e-43: 164: 13.39		KMT2E_HUMAN (27-574): 5.37e-09: 62.9: 9.45
+	Hs
		1052724 TRI25_HUMAN (63-387): 4.89e-43: 164: 13.39		CBP_HUMAN (4-844): 8.2e-09: 62.5: 8.68
+	Mm
		1206528 RNF41_MOUSE (55-204): 6.08e-18: 86.9: 30.77		SP130_MOUSE (26-696): 7.21e-11: 68.7: 10.13