Protein: RN220
E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)

Gene: RN220, RNF220
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q5VTB9

Gene Ontology (top 5):
GO:0003358 - noradrenergic neuron development
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005652 - nuclear lamina
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1217711

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

7

High-throughput

0.858

High

1217720

ZC4H2
Zinc finger C4H2 domain-containing protein

3

1

High-throughput

0.667

High

957095

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

7

Small-scale

0.647

High

982206

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

7

High-throughput

0.647

High

995975

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

8

High-throughput

0.647

High

1217710

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

0

Small-scale

0.623

High

998420

H31
Histone H3.1

1

1

High-throughput

0.618

High

1016931

H33
Histone H3.3

1

1

High-throughput

0.618

High

909324

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

7

High-throughput

0.590

High

1217713

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

8

High-throughput

0.590

High

1217715

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

7

High-throughput

0.590

High

274341

SIN3B
Paired amphipathic helix protein Sin3b

1

1

Small-scale

0.578

High

858953

RL27A
Large ribosomal subunit protein uL15

2

0

High-throughput

0.576

High

1115717

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.518

High

552985

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

964121

RL37
Large ribosomal subunit protein eL37

1

0

High-throughput

0.513

High

1217708

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.513

High

1217712

SPSB4
SPRY domain-containing SOCS box protein 4

1

0

High-throughput

0.513

High

1217714

ZN653
Zinc finger protein 653

1

0

High-throughput

0.513

High

1217722

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

838116

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.479

High

838457

GRIA1
Glutamate receptor 1

1

4

Small-scale

0.479

High

838498

GRIA2
Glutamate receptor 2

1

4

Small-scale

0.479

High

1217707

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1217717

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

1

Small-scale

0.479

High

1217718

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

Small-scale

0.479

High

1217716

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

Small-scale

0.460

High

1217719

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.460

High

315680

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

413999

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

634480

LMNB1
Lamin-B1

1

0

Small-scale

0.458

High

764824

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

891610

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.458

High

1045386

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1096039

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.458

High

1113346

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1217721

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

533685

CLUS
Clusterin

1

0

High-throughput

0.438

High

1143833

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.426

High

1217709

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

0

High-throughput

0.426

High

1217705

WDR5B
WD repeat-containing protein 5B

2

0

High-throughput

0.328

High

771073

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

0

High-throughput

0.282

High

288179

CLC3A
C-type lectin domain family 3 member A

1

0

High-throughput

0.279

Low

1203858

NOM1
Nucleolar MIF4G domain-containing protein 1

1

0

High-throughput

0.279

Low

1217706

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025