HitPredict

Interactor 1: SMAD1 (P70340)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1)
Gene: SMAD1

Interactor 2: UCHL3 (Q9JKB1)
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)
Gene: UCHL3

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36915132, 21453705
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Mm			1 230
+	Hs
		548101 SMAD1_HUMAN (1-465): 0: 653: 99.14		UCHL3_HUMAN (1-230): 6.58e-113: 324: 98.26
+	Hs
		950345 SMAD3_HUMAN (3-465): 0: 554: 59.44		UCHL5_HUMAN (1-228): 6.55e-96: 285: 28.51
+	Hs
		1078708 SMAD2_HUMAN (3-465): 0: 537: 55.14		UCHL5_HUMAN (1-228): 6.55e-96: 285: 28.51
+	Hs
		456545 SMAD3_HUMAN (3-465): 0: 554: 59.44		UCHL1_HUMAN (8-230): 6.03e-91: 268: 56.05
+	Hs
		456574 SMAD2_HUMAN (3-465): 0: 537: 55.14		UCHL1_HUMAN (8-230): 6.03e-91: 268: 56.05
+	Hs
		456561 SMAD4_HUMAN (8-454): 1.16e-150: 441: 33.15		UCHL1_HUMAN (8-230): 6.03e-91: 268: 56.05
+	Hs
		167415 SMAD7_HUMAN (30-131): 2.87e-25: 109: 32.46		UCHL5_HUMAN (1-228): 6.55e-96: 285: 28.51