HitPredict

Interactor 1: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Interactor 2: CD47 (Q08722)
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
Gene: CD47

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.870

The method score is based on:

Property Details
Experiments 33961781, 17070842, 16081415
Identification Methods affinity chromatography technology, solid phase assay, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains V-set~V-set_CD47
Common GO terms GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0016477 - cell migration
GO:0032649 - regulation of type II interferon production
GO:0032675 - regulation of interleukin-6 production
and 12 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 504
Hs

1 323
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024