HitPredict

Interactor 1: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23424281
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007612 - learning GO:0014069 - postsynaptic density GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 822
+	Mm
		546303 DLG4_MOUSE (1-724): 0: 667: 99.59		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Hs
		1049964 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607966 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		607940 EM55_HUMAN (2-325): 2.03e-22: 103: 14.41		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		1021503 DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		1081505 MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		384823 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		609253 EM55_HUMAN (2-325): 2.03e-22: 103: 14.41		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		385630 PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507995 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		384746 DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		159135 CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		609417 PALS1_HUMAN (3-238): 7.09e-18: 90.2: 12.30		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		385214 DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		508052 MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		159144 CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		508118 DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		435639 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Rn
		88514 MPP2_RAT (2-383): 4.77e-22: 102: 14.79		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		169176 SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72		MUSK_HUMAN (193-374): 7.66e-18: 90.5: 22.92