Protein: RYR2
Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)

Gene: RYR2
Organism: Mus musculus
Interactions: 68
UniProt ID: E9Q401

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0002027 - regulation of heart rate
GO:0003143 - embryonic heart tube morphogenesis
GO:0003220 - left ventricular cardiac muscle tissue morphogenesis
GO:0003300 - cardiac muscle hypertrophy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

97930

RYR2
Ryanodine receptor 2

3

16

Small-scale

0.822

High

97992

FKB1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

2

10

Small-scale

0.776

High

97957

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

2

10

Small-scale

0.737

High

97969

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

11

Small-scale

0.737

High

97931

E9Q9K8
A-kinase anchor protein 6

1

9

Small-scale

0.618

High

97934

PKD2
Polycystin-2

1

20

Small-scale

0.618

High

97968

SORCN
Sorcin

1

7

Small-scale

0.618

High

97678

E9PV66
Myosin XVIIIb

1

10

High-throughput

0.575

High

97718

E9PX29
Spectrin beta chain

1

7

High-throughput

0.575

High

97809

RYR1
Ryanodine receptor 1

1

17

High-throughput

0.575

High

97963

MYH1
Myosin-1

1

11

High-throughput

0.575

High

97989

PLEC
Plectin

1

9

High-throughput

0.575

High

97962

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

7

High-throughput

0.514

High

97967

SPEG
Striated muscle-specific serine/threonine-protein kinase

1

12

High-throughput

0.514

High

97970

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

High-throughput

0.514

High

97973

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

5

High-throughput

0.514

High

97978

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

6

Small-scale

0.500

High

97941

GRIA2
Glutamate receptor 2

1

6

High-throughput

0.479

High

97965

PSN2
Presenilin-2

1

1

Small-scale

0.479

High

97958

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.457

High

97937

MYPC3
Myosin-binding protein C, cardiac-type

1

12

High-throughput

0.445

High

97947

CAV3
Caveolin-3

1

3

High-throughput

0.445

High

97950

1433Z
14-3-3 protein zeta/delta

1

15

High-throughput

0.445

High

97953

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.445

High

97960

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.445

High

97966

SNTA1
Alpha-1-syntrophin

1

2

High-throughput

0.445

High

97977

LRC10
Leucine-rich repeat-containing protein 10

1

5

High-throughput

0.445

High

97944

DYN2
Dynamin-2

1

1

High-throughput

0.417

High

97988

COPB
Coatomer subunit beta

1

1

High-throughput

0.417

High

97537

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

8

High-throughput

0.407

High

97932

KNG1
Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain]

1

5

High-throughput

0.407

High

97933

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.407

High

97936

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.407

High

97938

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.407

High

97939

FABPH
Fatty acid-binding protein, heart

1

2

High-throughput

0.407

High

97940

CATD
Cathepsin D

1

1

High-throughput

0.407

High

97945

AINX
Alpha-internexin

1

9

High-throughput

0.407

High

97946

PSA2
Proteasome subunit alpha type-2

1

3

High-throughput

0.407

High

97948

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

4

High-throughput

0.407

High

97951

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.407

High

97952

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.407

High

97954

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.407

High

97955

H33
Histone H3.3

1

4

High-throughput

0.407

High

97956

G3BP2
Ras GTPase-activating protein-binding protein 2

1

6

High-throughput

0.407

High

97959

C1QC
Complement C1q subcomponent subunit C

1

2

High-throughput

0.407

High

97961

COBL1
Cordon-bleu protein-like 1

1

6

High-throughput

0.407

High

97964

IRAG2
Inositol 1,4,5-triphosphate receptor associated 2

1

3

High-throughput

0.407

High

97971

TBB2A
Tubulin beta-2A chain

1

2

High-throughput

0.407

High

97974

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

4

High-throughput

0.407

High

97975

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.407

High

97976

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

8

High-throughput

0.407

High

97979

FIBG
Fibrinogen gamma chain

1

8

High-throughput

0.407

High

97980

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

High-throughput

0.407

High

97981

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

10

High-throughput

0.407

High

97982

SPA3N
Serine protease inhibitor A3N

1

5

High-throughput

0.407

High

97983

NONO
Non-POU domain-containing octamer-binding protein

1

9

High-throughput

0.407

High

97985

EF1G
Elongation factor 1-gamma

1

4

High-throughput

0.407

High

97986

HRG
Histidine-rich glycoprotein

1

4

High-throughput

0.407

High

97987

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

6

High-throughput

0.407

High

97990

PSA4
Proteasome subunit alpha type-4

1

3

High-throughput

0.407

High

97991

SYVC
Valine--tRNA ligase

1

4

High-throughput

0.407

High

97935

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.232

Low

97942

CTNA1
Catenin alpha-1

1

0

High-throughput

0.232

Low

97943

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.232

Low

97949

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.232

Low

97972

SPAT7
Spermatogenesis-associated protein 7 homolog

1

0

High-throughput

0.232

Low

97984

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025