HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: CLASR (Q8N2M8)
CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2)
Gene: CLASRP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	26167880, 33961781, 23602568
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 674
+	Hs
		1231710 DYRK2_HUMAN (51-234): 1.48e-62: 221: 29.35		CLASR_HUMAN (1-674): 3.86e-87: 288: 100.00
+	Hs
		833922 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		CLASR_HUMAN (1-674): 3.86e-87: 288: 100.00
+	Hs
		834081 CLK3_HUMAN (62-240): 6.66e-62: 220: 31.11		CLASR_HUMAN (1-674): 3.86e-87: 288: 100.00
+	Hs
		1231722 CLK4_HUMAN (52-230): 6.32e-62: 216: 30.56		CLASR_HUMAN (1-674): 3.86e-87: 288: 100.00
+	Hs
		833771 CLK1_HUMAN (52-226): 1.37e-61: 215: 31.25		CLASR_HUMAN (1-674): 3.86e-87: 288: 100.00
+	Sp
		736990 DSK1_SCHPO (437-686): 7.4e-74: 250: 44.40		THO2_SCHPO (256-657): 3.35e-46: 179: 15.57
+	Sp
		999904 LKH1_SCHPO (492-687): 1.24e-59: 214: 24.63		THO2_SCHPO (256-657): 3.35e-46: 179: 15.57
+	Dm
		834194 DOA_DROME (519-687): 7.73e-14: 77: 29.12		Q9VC60_DROME (199-647): 3.37e-11: 68.6: 15.65
+	Dm
		834170 DOA_DROME (519-687): 7.73e-14: 77: 29.12		Q7YZ99_DROME (193-652): 3.01e-10: 65.9: 13.91