HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: SREK1 (Q8WXA9)
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)
Gene: SREK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.882

The method score is based on:

Property Details
Experiments 33961781, 32707033, 23602568
Identification Methods affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~RRM_1
Common GO terms GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0008380 - RNA splicing
GO:0016607 - nuclear speck
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 688
Hs

1 508
+ Hs
+ Hs
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+ Hs
+ Sp
+ Sp
+ Dm
+ Hs
+ Dm
+ Dm

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Last updated: 15 Jul 2024