HitPredict

Interactor 1: KPCI (F1M7Y5)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: Prkci

Interactor 2: SQSTM (O08623)
Sequestosome-1 (Protein kinase C-zeta-interacting protein) (PKC-zeta-interacting protein) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	11500922, 26199377, 23511975
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 596 Rn			1 439
+	Rn
		139612 KPCZ_RAT (23-596): 0: 604: 71.31		SQSTM_RAT (1-439): 0: 782: 100.00
+	Hs
		784001 KPCI_HUMAN (1-596): 0: 671: 98.66		SQSTM_HUMAN (1-439): 0: 713: 88.46
+	Mm
		973811 KPCZ_MOUSE (23-596): 0: 599: 70.96		SQSTM_MOUSE (1-439): 0: 772: 96.83
+	Hs
		983828 KPCZ_HUMAN (19-596): 0: 603: 70.48		SQSTM_HUMAN (1-439): 0: 713: 88.46
+	Rn
		139610 KPCD_RAT (100-587): 1.67e-174: 512: 35.85		SQSTM_RAT (1-439): 0: 782: 100.00
+	Mm
		661009 KPCD_MOUSE (100-589): 2.2e-175: 514: 35.90		SQSTM_MOUSE (1-439): 0: 772: 96.83
+	Hs
		984491 KPCD_HUMAN (100-589): 4.69e-175: 513: 34.95		SQSTM_HUMAN (1-439): 0: 713: 88.46
+	Hs
		616709 KS6B1_HUMAN (233-592): 6.07e-149: 441: 37.64		SQSTM_HUMAN (1-439): 0: 713: 88.46
+	Rn
		139611 KPCE_RAT (29-212): 1.08e-19: 95.4: 18.78		SQSTM_RAT (1-439): 0: 782: 100.00
+	Rn
		139620 KPCB_RAT (111-194): 2e-17: 88: 29.76		SQSTM_RAT (1-439): 0: 782: 100.00
+	Rn
		139624 KPCL_RAT (21-190): 1.14e-16: 85.8: 21.98		SQSTM_RAT (1-439): 0: 782: 100.00
+	Rn
		139619 KPCG_RAT (126-190): 2.42e-12: 72: 43.08		SQSTM_RAT (1-439): 0: 782: 100.00
+	Dm
		54642 APKC_DROME (1-596): 0: 620: 66.17		REF2P_DROME (110-167): 1.12e-17: 87.5: 41.67