Protein: KLHL2
Kelch-like protein 2 (Actin-binding protein Mayven)

Gene: KLHL2
Organism: Homo sapiens
Interactions: 95
UniProt ID: O95198

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329059

CUL3
Cullin-3

10

20

Small-scale

0.973

High

329071

KLH12
Kelch-like protein 12

8

19

Small-scale

0.968

High

329061

KEAP1
Kelch-like ECH-associated protein 1

6

18

Small-scale

0.948

High

329043

KLHL2
Kelch-like protein 2

5

18

Small-scale

0.922

High

329117

KLHL3
Kelch-like protein 3

4

19

High-throughput

0.894

High

329116

FXL17
F-box/LRR-repeat protein 17

3

16

High-throughput

0.861

High

329077

KLH17
Kelch-like protein 17

3

18

High-throughput

0.839

High

329066

CUL7
Cullin-7

2

1

High-throughput

0.789

High

329048

BCAM
Basal cell adhesion molecule

2

10

High-throughput

0.755

High

329096

NACC1
Nucleus accumbens-associated protein 1

1

18

Small-scale

0.713

High

329063

GIT2
ARF GTPase-activating protein GIT2

2

4

High-throughput

0.705

High

329106

WNK1
Serine/threonine-protein kinase WNK1

4

15

Small-scale

0.683

High

329107

UCK1
Uridine-cytidine kinase 1

3

1

Small-scale

0.678

High

329062

ARHG7
Rho guanine nucleotide exchange factor 7

3

6

Small-scale

0.656

High

329097

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

12

Small-scale

0.656

High

329101

WNK3
Serine/threonine-protein kinase WNK3

3

9

Small-scale

0.656

High

329090

TMA16
Translation machinery-associated protein 16

4

1

High-throughput

0.637

High

329092

WNK4
Serine/threonine-protein kinase WNK4

2

10

Small-scale

0.633

High

140088

SDCB1
Syntenin-1

2

6

High-throughput

0.628

High

164498

TNPO2
Transportin-2

2

2

High-throughput

0.628

High

329058

DCTN2
Dynactin subunit 2

3

0

High-throughput

0.628

High

329047

CLK2
Dual specificity protein kinase CLK2

3

1

High-throughput

0.616

High

143984

P3C2B
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

2

3

High-throughput

0.611

High

271785

OBSL1
Obscurin-like protein 1

2

5

High-throughput

0.611

High

273463

DJC13
DnaJ homolog subfamily C member 13

2

11

High-throughput

0.611

High

329046

ACTY
Beta-centractin

2

10

High-throughput

0.611

High

329051

ACTZ
Alpha-centractin

2

10

High-throughput

0.611

High

329056

XIAP
E3 ubiquitin-protein ligase XIAP

2

2

High-throughput

0.611

High

329064

DCTN1
Dynactin subunit 1

2

4

High-throughput

0.611

High

329084

FBXW8
F-box/WD repeat-containing protein 8

2

4

High-throughput

0.611

High

329088

UPP
Uracil phosphoribosyltransferase homolog

2

1

High-throughput

0.611

High

329089

GASP2
G-protein coupled receptor-associated sorting protein 2

2

1

High-throughput

0.611

High

329093

SCYL1
N-terminal kinase-like protein

2

4

High-throughput

0.611

High

329094

TRI47
E3 ubiquitin-protein ligase TRIM47

2

8

High-throughput

0.611

High

329099

DCTN5
Dynactin subunit 5

2

1

High-throughput

0.611

High

329102

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

8

High-throughput

0.611

High

329103

TRIM9
E3 ubiquitin-protein ligase TRIM9

2

9

High-throughput

0.611

High

329111

UCKL1
Uridine-cytidine kinase-like 1

2

2

High-throughput

0.611

High

329113

ARP10
Actin-related protein 10

2

9

High-throughput

0.611

High

329119

DP13A
DCC-interacting protein 13-alpha

2

4

High-throughput

0.611

High

329120

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

4

High-throughput

0.611

High

329060

BYST
Bystin

2

1

High-throughput

0.606

High

329068

CDC37
Hsp90 co-chaperone Cdc37

2

1

High-throughput

0.606

High

329078

PADI6
Inactive protein-arginine deiminase type-6

2

1

High-throughput

0.606

High

329082

TRI50
E3 ubiquitin-protein ligase TRIM50

2

2

High-throughput

0.606

High

329091

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

3

High-throughput

0.606

High

329052

TSN5
Tetraspanin-5

3

2

High-throughput

0.599

High

133330

DCTN6
Dynactin subunit 6

2

0

High-throughput

0.585

High

208609

SI1L1
Signal-induced proliferation-associated 1-like protein 1

2

0

High-throughput

0.585

High

298131

DCTN3
Dynactin subunit 3

2

0

High-throughput

0.585

High

329045

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.585

High

329080

FBX33
F-box only protein 33

2

0

High-throughput

0.585

High

329098

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.585

High

329104

CCDC8
Coiled-coil domain-containing protein 8

2

0

High-throughput

0.585

High

329109

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.585

High

329118

DCTN4
Dynactin subunit 4

2

0

High-throughput

0.585

High

329123

SYYM
Tyrosine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

329100

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

329108

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

0

High-throughput

0.580

High

329115

KLH13
Kelch-like protein 13

1

18

High-throughput

0.575

High

329095

CCD43
Coiled-coil domain-containing protein 43

1

1

High-throughput

0.573

High

329055

ACTC
Actin, alpha cardiac muscle 1

1

8

Small-scale

0.561

High

329075

PHLB3
Pleckstrin homology-like domain family B member 3

2

4

High-throughput

0.558

High

329065

ELOA1
Elongin-A

2

1

High-throughput

0.553

High

329105

CMIP1
Ciliary microtubule inner protein 1

2

1

High-throughput

0.553

High

329081

Q86WV7
Coiled-coil domain-containing protein 43

1

1

High-throughput

0.542

High

329057

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

6

High-throughput

0.536

High

329083

NUDC3
NudC domain-containing protein 3

1

20

High-throughput

0.536

High

329112

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

1

1

High-throughput

0.536

High

329073

Q5TZN3
Ubiquitin-conjugating enzyme E2 C

1

7

High-throughput

0.515

High

329072

KLH26
Kelch-like protein 26

1

18

High-throughput

0.514

High

329049

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.501

High

67745

TBKB1
TANK-binding kinase 1-binding protein 1

1

3

Small-scale

0.481

High

144154

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

7

High-throughput

0.481

High

329054

UBC9
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.481

High

329087

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

168604

CSKP
Peripheral plasma membrane protein CASK

1

4

High-throughput

0.479

High

329124

WNK2
Serine/threonine-protein kinase WNK2

1

12

Small-scale

0.479

High

329125

ARI1
E3 ubiquitin-protein ligase ARIH1

1

13

High-throughput

0.479

High

329070

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

329079

Q7KZS0
SUMO-conjugating enzyme UBC9

1

10

High-throughput

0.470

High

329067

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.458

High

329110

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

329053

SKP1
S-phase kinase-associated protein 1

1

4

High-throughput

0.445

High

329086

CC150
Coiled-coil domain-containing protein 150

1

6

High-throughput

0.437

High

329114

RRBP1
Ribosome-binding protein 1

1

8

High-throughput

0.437

High

329085

ZN114
Zinc finger protein 114

4

0

High-throughput

0.364

High

329044

TXD12
Thioredoxin domain-containing protein 12

3

0

High-throughput

0.348

High

329074

FHI2A
FHF complex subunit HOOK interacting protein 2A

2

0

High-throughput

0.318

High

329050

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.316

High

329121

NP1L2
Nucleosome assembly protein 1-like 2

2

0

High-throughput

0.316

High

329069

ZN423
Zinc finger protein 423

1

0

High-throughput

0.279

Low

329076

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.249

Low

329122

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025