HitPredict

Interactor 1: RAE1L (P78406)
mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41)
Gene: RAE1

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	17172455, 35271311
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008017 - microtubule binding GO:0051301 - cell division GO:0060236 - regulation of mitotic spindle organization and 1 others more... GO:0097431 - mitotic spindle pole
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 368 Hs			1 2115
+	Hs
		1061204 SNR40_HUMAN (258-358): 1.55e-20: 93.1: 15.69		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		943814 RAE1L_HUMAN (1-368): 5.99e-98: 296: 100.00		CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63
+	Hs
		792973 LIS1_HUMAN (1-72): 3.58e-14: 75: 18.29		CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63
+	Hs
		903240 WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Mm
		925837 LIS1_MOUSE (1-72): 3.21e-14: 75.4: 18.29		Q155P7_MOUSE (562-1890): 5.59e-30: 133: 11.42
+	Hs
		903233 WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75		GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49
+	Hs
		518846 WDR5_HUMAN (247-367): 7.8e-24: 102: 14.75		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		728492 POC1A_HUMAN (258-342): 6.64e-18: 86.2: 14.12		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41