Protein: SMAD1
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)

Gene: SMAD1
Organism: Homo sapiens
Interactions: 185
UniProt ID: Q15797

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1035446

SMAD4
Mothers against decapentaplegic homolog 4

16

19

Small-scale

0.985

High

206964

SMAD6
Mothers against decapentaplegic homolog 6

4

19

Small-scale

0.900

High

1078713

SMAD1
Mothers against decapentaplegic homolog 1

3

19

Small-scale

0.868

High

521278

SKI
Ski oncogene

3

16

Small-scale

0.857

High

1078555

SMAD2
Mothers against decapentaplegic homolog 2

3

19

Small-scale

0.849

High

950194

SMAD3
Mothers against decapentaplegic homolog 3

2

19

Small-scale

0.783

High

1078761

SMUF1
E3 ubiquitin-protein ligase SMURF1

17

20

Small-scale

0.767

High

1078760

SMUF2
E3 ubiquitin-protein ligase SMURF2

11

20

Small-scale

0.759

High

656470

PSB4
Proteasome subunit beta type-4

6

1

Small-scale

0.733

High

1078782

MAN1
Inner nuclear membrane protein Man1

5

14

Small-scale

0.717

High

998756

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.702

High

1078777

CHIP
E3 ubiquitin-protein ligase CHIP

3

6

Small-scale

0.692

High

808645

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.660

High

1078750

SMAD5
Mothers against decapentaplegic homolog 5

1

20

High-throughput

0.656

High

658955

MK01
Mitogen-activated protein kinase 1

3

3

Small-scale

0.655

High

1078735

CBP
CREB-binding protein

3

19

Small-scale

0.646

High

981121

ACVR1
Activin receptor type-1

3

20

Small-scale

0.642

High

1047413

RUNX2
Runt-related transcription factor 2

3

16

Small-scale

0.640

High

487474

ANDR
Androgen receptor

2

14

Small-scale

0.639

High

1078729

PIAS4
E3 SUMO-protein ligase PIAS4

2

16

Small-scale

0.627

High

738353

BMR1A
Bone morphogenetic protein receptor type-1A

2

20

Small-scale

0.619

High

167367

SMAD7
Mothers against decapentaplegic homolog 7

1

18

Small-scale

0.618

High

521363

SKIL
Ski-like protein

1

16

Small-scale

0.618

High

307532

EPN2
Epsin-2

2

3

High-throughput

0.606

High

739529

ACVL1
Serine/threonine-protein kinase receptor R3

2

20

Small-scale

0.602

High

270506

MED6
Mediator of RNA polymerase II transcription subunit 6

2

2

Small-scale

0.601

High

231242

ZEB2
Zinc finger E-box-binding homeobox 2

2

15

Small-scale

0.600

High

808135

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.600

High

1054770

CASL
Enhancer of filamentation 1

2

5

Small-scale

0.600

High

1078722

ZCH12
Zinc finger CCHC domain-containing protein 12

2

0

Small-scale

0.598

High

122787

MEN1
Menin

2

5

Small-scale

0.584

High

1078717

ZN423
Zinc finger protein 423

2

5

Small-scale

0.584

High

1078738

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

7

Small-scale

0.584

High

1078757

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

20

Small-scale

0.584

High

1078786

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

13

Small-scale

0.584

High

826282

CDK8
Cyclin-dependent kinase 8

1

10

Small-scale

0.578

High

678916

HXC8
Homeobox protein Hox-C8

1

12

Small-scale

0.573

High

178172

IPO8
Importin-8

1

6

Small-scale

0.561

High

943104

NKX32
Homeobox protein Nkx-3.2

1

12

Small-scale

0.561

High

1078721

TAPT1
Transmembrane anterior posterior transformation protein 1 homolog

1

1

Small-scale

0.561

High

1078758

HIPK2
Homeodomain-interacting protein kinase 2

1

18

Small-scale

0.561

High

571470

DDX5
Probable ATP-dependent RNA helicase DDX5

1

10

Small-scale

0.554

High

1078763

RNC
Ribonuclease 3

1

3

Small-scale

0.554

High

1078751

MEP50
Methylosome protein WDR77

1

5

Small-scale

0.552

High

211019

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.541

High

237498

TLR2
Toll-like receptor 2

1

1

High-throughput

0.541

High

257475

CREST
Calcium-responsive transactivator

1

5

High-throughput

0.541

High

348680

RASN
GTPase NRas

1

2

High-throughput

0.541

High

383827

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

2

High-throughput

0.541

High

595603

HXA5
Homeobox protein Hox-A5

1

10

High-throughput

0.541

High

626141

APC
Adenomatous polyposis coli protein

1

3

High-throughput

0.541

High

776328

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.541

High

983489

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

2

High-throughput

0.541

High

1078716

NF2L2
Nuclear factor erythroid 2-related factor 2

1

15

Small-scale

0.541

High

1078740

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.541

High

1078746

RHG07
Rho GTPase-activating protein 7

1

4

High-throughput

0.541

High

1078770

MLH3
DNA mismatch repair protein Mlh3

1

1

High-throughput

0.541

High

1078781

AXIN2
Axin-2

1

6

High-throughput

0.541

High

571141

EGLN
Endoglin

1

1

High-throughput

0.536

High

957403

IDD
Integral membrane protein DGCR2/IDD

1

4

High-throughput

0.536

High

1078724

KDM3B
Lysine-specific demethylase 3B

1

5

High-throughput

0.536

High

1078728

TM192
Transmembrane protein 192

1

2

High-throughput

0.536

High

1078720

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

622473

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.518

High

716691

CTNA1
Catenin alpha-1

1

0

High-throughput

0.518

High

794261

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.518

High

1078772

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.518

High

265331

MED24
Mediator of RNA polymerase II transcription subunit 24

1

5

Small-scale

0.515

High

548101

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

7

Small-scale

0.515

High

1078747

MED15
Mediator of RNA polymerase II transcription subunit 15

1

16

Small-scale

0.515

High

1078741

OPTN
Optineurin

1

3

High-throughput

0.515

High

121772

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

High-throughput

0.508

High

152653

KMT2D
Histone-lysine N-methyltransferase 2D

1

14

High-throughput

0.508

High

164695

MAST4
Microtubule-associated serine/threonine-protein kinase 4

1

20

High-throughput

0.508

High

233844

HBP1
HMG box-containing protein 1

1

20

High-throughput

0.508

High

268737

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.508

High

278098

PIAS1
E3 SUMO-protein ligase PIAS1

1

16

High-throughput

0.508

High

302156

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.508

High

442186

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.508

High

610163

RFX1
MHC class II regulatory factor RFX1

1

7

High-throughput

0.508

High

727747

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.508

High

735053

ZNF76
Zinc finger protein 76

1

4

High-throughput

0.508

High

980382

NOTC2
Neurogenic locus notch homolog protein 2

1

11

High-throughput

0.508

High

1071727

TTF1
Transcription termination factor 1

1

1

High-throughput

0.508

High

1078718

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

1

High-throughput

0.508

High

1078727

MGAP
MAX gene-associated protein

1

4

High-throughput

0.508

High

1078730

ZSCA4
Zinc finger and SCAN domain-containing protein 4

1

4

High-throughput

0.508

High

1078734

SFRP3
Secreted frizzled-related protein 3

1

2

High-throughput

0.508

High

1078739

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

2

High-throughput

0.508

High

1078743

Z512B
Zinc finger protein 512B

1

2

High-throughput

0.508

High

1078744

ANR27
Ankyrin repeat domain-containing protein 27

1

4

High-throughput

0.508

High

1078745

INP4A
Inositol polyphosphate-4-phosphatase type I A

1

1

High-throughput

0.508

High

1078754

ZN251
Zinc finger protein 251

1

1

High-throughput

0.508

High

1078775

MRTFB
Myocardin-related transcription factor B

1

9

High-throughput

0.508

High

1078778

TTF2
Transcription termination factor 2

1

5

High-throughput

0.508

High

1078779

CILK1
Serine/threonine-protein kinase ICK

1

3

High-throughput

0.508

High

1078780

ZN510
Zinc finger protein 510

1

3

High-throughput

0.508

High

1078784

CHMP3
Charged multivesicular body protein 3

1

3

High-throughput

0.508

High

1078785

STA13
StAR-related lipid transfer protein 13

1

4

High-throughput

0.508

High

1078788

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

1

High-throughput

0.508

High

150710

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

18

Small-scale

0.501

High

394773

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

632748

TYY1
Transcriptional repressor protein YY1

1

11

Small-scale

0.501

High

805424

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

17

High-throughput

0.501

High

835780

GSK3B
Glycogen synthase kinase-3 beta

1

8

Small-scale

0.501

High

841213

CDK7
Cyclin-dependent kinase 7

1

2

Small-scale

0.501

High

841751

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.501

High

877615

FOXG1
Forkhead box protein G1

1

7

Small-scale

0.501

High

974577

MECOM
Histone-lysine N-methyltransferase MECOM

1

18

Small-scale

0.501

High

1078714

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.501

High

1078732

PARD3
Partitioning defective 3 homolog

1

6

Small-scale

0.501

High

1078737

NGN1
Neurogenin-1

1

3

Small-scale

0.501

High

1078748

ERBIN
Erbin

1

10

Small-scale

0.501

High

1078771

DACH1
Dachshund homolog 1

1

2

High-throughput

0.501

High

1078774

DNM3L
DNA

1

2

Small-scale

0.501

High

1069586

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.494

High

544741

ALDR
Aldo-keto reductase family 1 member B1

1

0

High-throughput

0.486

High

967034

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.486

High

1056654

PUM1
Pumilio homolog 1

1

0

High-throughput

0.486

High

1078726

I2BP1
Interferon regulatory factor 2-binding protein 1

1

0

High-throughput

0.486

High

1078749

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.486

High

1078766

ZDHC3
Palmitoyltransferase ZDHHC3

1

0

High-throughput

0.486

High

359979

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.481

High

475815

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

7

Small-scale

0.481

High

870304

OAZ1
Ornithine decarboxylase antizyme 1

1

1

Small-scale

0.481

High

1078731

SNIP1
Smad nuclear-interacting protein 1

1

2

Small-scale

0.481

High

1078769

TCF20
Transcription factor 20

1

4

High-throughput

0.481

High

1078776

OAZ3
Ornithine decarboxylase antizyme 3

1

1

Small-scale

0.481

High

48674

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

Small-scale

0.479

High

127277

IPO5
Importin-5

1

4

Small-scale

0.479

High

149984

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

6

Small-scale

0.479

High

160011

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.479

High

162781

XPO1
Exportin-1

1

9

High-throughput

0.479

High

165855

KDM6B
Lysine-specific demethylase 6B

1

10

Small-scale

0.479

High

171217

CTDSL
CTD small phosphatase-like protein

1

6

Small-scale

0.479

High

206841

FOXO3
Forkhead box protein O3

1

18

Small-scale

0.479

High

225383

MED14
Mediator of RNA polymerase II transcription subunit 14

1

6

Small-scale

0.479

High

312278

IPO7
Importin-7

1

7

Small-scale

0.479

High

331519

ACL6A
Actin-like protein 6A

1

2

Small-scale

0.479

High

386809

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

575453

EGR1
Early growth response protein 1

1

6

High-throughput

0.479

High

600151

TAF1
Transcription initiation factor TFIID subunit 1

1

20

Small-scale

0.479

High

641418

PAX6
Paired box protein Pax-6

1

4

Small-scale

0.479

High

727261

NU214
Nuclear pore complex protein Nup214

1

8

Small-scale

0.479

High

728612

PPM1A
Protein phosphatase 1A

1

2

Small-scale

0.479

High

741056

ZEB1
Zinc finger E-box-binding homeobox 1

1

20

Small-scale

0.479

High

776698

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.479

High

836233

TAF6
Transcription initiation factor TFIID subunit 6

1

1

Small-scale

0.479

High

841388

TOB1
Protein Tob1

1

11

Small-scale

0.479

High

848224

HCFC1
Host cell factor 1

1

1

Small-scale

0.479

High

857473

HMGA2
High mobility group protein HMGI-C

1

3

Small-scale

0.479

High

933460

TBA4A
Tubulin alpha-4A chain

1

2

Small-scale

0.479

High

964344

RUNX1
Runt-related transcription factor 1

1

16

Small-scale

0.479

High

1036602

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

1038410

HDAC1
Histone deacetylase 1

1

12

Small-scale

0.479

High

1045124

RUNX3
Runt-related transcription factor 3

1

16

Small-scale

0.479

High

1057764

NCOA6
Nuclear receptor coactivator 6

1

5

Small-scale

0.479

High

1074703

MED22
Mediator of RNA polymerase II transcription subunit 22

1

1

Small-scale

0.479

High

1074786

TAF5
Transcription initiation factor TFIID subunit 5

1

4

Small-scale

0.479

High

1075356

TGIF1
Homeobox protein TGIF1

1

11

Small-scale

0.479

High

1078715

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

Small-scale

0.479

High

1078719

TAF3
Transcription initiation factor TFIID subunit 3

1

7

Small-scale

0.479

High

1078723

MED25
Mediator of RNA polymerase II transcription subunit 25

1

1

Small-scale

0.479

High

1078725

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

3

Small-scale

0.479

High

1078733

TF3C2
General transcription factor 3C polypeptide 2

1

1

Small-scale

0.479

High

1078736

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

1078742

ZN521
Zinc finger protein 521

1

5

Small-scale

0.479

High

1078752

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

2

Small-scale

0.479

High

1078755

FOXP3
Forkhead box protein P3

1

6

Small-scale

0.479

High

1078756

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

6

Small-scale

0.479

High

1078759

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

Small-scale

0.479

High

1078762

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

Small-scale

0.479

High

1078764

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

Small-scale

0.479

High

1078765

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

Small-scale

0.479

High

1078767

CXXC1
CXXC-type zinc finger protein 1

1

5

Small-scale

0.479

High

1078768

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

8

Small-scale

0.479

High

1078773

LEF1
Lymphoid enhancer-binding factor 1

1

20

Small-scale

0.479

High

1078783

MED16
Mediator of RNA polymerase II transcription subunit 16

1

2

Small-scale

0.479

High

254901

CPNE3
Copine-3

1

0

High-throughput

0.458

High

1078787

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.458

High

967203

EWS
RNA-binding protein EWS

1

8

High-throughput

0.457

High

61978

FA83G
Protein FAM83G

1

2

Small-scale

0.445

High

540293

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

1078753

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024