HitPredict

Interactor 1: IRX1 (P78414)
Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1)
Gene: IRX1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19934318
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0010628 - positive regulation of gene expression
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 467
+	Hs
		1075355 TGIF1_HUMAN (4-365): 1.66e-43: 159: 18.45		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Mm
		784126 PBX1_MOUSE (126-340): 4.07e-41: 154: 16.28		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Hs
		950189 TGIF1_HUMAN (4-365): 1.66e-43: 159: 18.45		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		784128 PBX1_MOUSE (126-340): 4.07e-41: 154: 16.28		SMAD3_MOUSE (1-467): 0: 617: 83.94
+	Dm
		53699 A1Z913_DROME (128-406): 1.16e-45: 168: 19.37		MAD_DROME (1-467): 0: 586: 55.90
+	Hs
		950275 TGIF2_HUMAN (126-348): 1.06e-35: 134: 21.55		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1075356 TGIF1_HUMAN (4-365): 1.66e-43: 159: 18.45		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Dm
		53697 A1Z913_DROME (128-406): 1.16e-45: 168: 19.37		O96660_DROME (4-467): 0: 524: 55.13
+	Mm
		784123 PBX1_MOUSE (126-340): 4.07e-41: 154: 16.28		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46