Interactor 1: JAG1 (P78504)
Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339)
Gene: JAG1

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.876

The method score is based on:

Property Details
Experiments 11346656, 10551863, 10958687
Identification Methods affinity chromatography technology, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DSL~EGF_CA, EGF~EGF, EGF~EGF_CA, EGF_CA~EGF_CA, EGF_CA~MNNL
Common GO terms GO:0001709 - cell fate determination
GO:0002011 - morphogenesis of an epithelial sheet
GO:0003184 - pulmonary valve morphogenesis
GO:0005112 - Notch binding
GO:0005509 - calcium ion binding
and 9 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1218
Hs

1 2471
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+ Dr

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Last updated: 15 Jul 2024