Protein: YMEL1
ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)

Gene: YMEL1, YME1L1
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q96TA2

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

525608

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

High-throughput

0.640

High

370267

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

228450

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.618

High

1303097

CLPB
Mitochondrial disaggregase

1

5

High-throughput

0.618

High

1303103

Q9H4D1
Protein kinase

1

3

High-throughput

0.618

High

1303129

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.618

High

385394

NTRK1
High affinity nerve growth factor receptor

2

4

High-throughput

0.594

High

274607

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

1

High-throughput

0.584

High

325337

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

2

High-throughput

0.584

High

1183200

COX15
Heme A synthase COX15

2

1

High-throughput

0.584

High

1303095

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

1

High-throughput

0.584

High

1303110

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

1303118

OCAD1
OCIA domain-containing protein 1

2

2

High-throughput

0.584

High

1303124

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

476248

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.579

High

883612

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.575

High

1303117

ATD3A
ATPase family AAA domain-containing protein 3A

1

5

High-throughput

0.575

High

1298659

ODAD4
Outer dynein arm-docking complex subunit 4

2

2

High-throughput

0.574

High

1175121

TBA1A
Tubulin alpha-1A chain

2

3

High-throughput

0.571

High

231147

OPA1
Dynamin-like GTPase OPA1, mitochondrial

2

0

High-throughput

0.559

High

1303126

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

Small-scale

0.553

High

549921

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

1

High-throughput

0.536

High

678577

MK04
Mitogen-activated protein kinase 4

1

2

High-throughput

0.536

High

794418

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.536

High

863798

LIMK1
LIM domain kinase 1

1

3

High-throughput

0.536

High

863843

LIMK2
LIM domain kinase 2

1

1

High-throughput

0.536

High

968906

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

1051051

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1085245

PDK4
[Pyruvate dehydrogenase

1

2

High-throughput

0.536

High

1160277

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.536

High

1197678

NEK8
Serine/threonine-protein kinase Nek8

1

1

High-throughput

0.536

High

1198837

ADCK1
AarF domain-containing protein kinase 1

1

3

High-throughput

0.536

High

1200404

ST32C
Serine/threonine-protein kinase 32C

1

2

High-throughput

0.536

High

1205234

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

1

High-throughput

0.536

High

1242897

HIPK4
Homeodomain-interacting protein kinase 4

1

2

High-throughput

0.536

High

1245367

NEK11
Serine/threonine-protein kinase Nek11

1

1

High-throughput

0.536

High

1246630

COQ8A
Atypical kinase COQ8A, mitochondrial

1

3

High-throughput

0.536

High

1274509

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1287829

COQ8B
Atypical kinase COQ8B, mitochondrial

1

3

High-throughput

0.536

High

1303099

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

1

High-throughput

0.536

High

1303112

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

1

High-throughput

0.536

High

1303121

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.536

High

1303123

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

2

High-throughput

0.536

High

1303098

BC11A
B-cell lymphoma/leukemia 11A

1

0

High-throughput

0.518

High

1303136

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.515

High

118984

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

217350

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

529612

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

777250

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.513

High

1082095

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.513

High

1160172

S39A4
Zinc transporter ZIP4

1

0

High-throughput

0.513

High

1284424

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

1303094

STK33
Serine/threonine-protein kinase 33

1

0

High-throughput

0.513

High

1303108

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1303113

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

0

High-throughput

0.513

High

1303128

INTU
Protein inturned

1

1

High-throughput

0.489

High

118413

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

204033

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.479

High

276870

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

295159

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

297090

TOM70
Mitochondrial import receptor subunit TOM70

1

2

High-throughput

0.479

High

308995

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

319310

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

335852

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.479

High

347671

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

371129

NU2M
NADH-ubiquinone oxidoreductase chain 2

1

1

Small-scale

0.479

High

371238

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

Small-scale

0.479

High

377626

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

486615

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

553512

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

652040

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

801937

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

843004

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

845192

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

925550

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

1042355

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1066570

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1074632

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1118925

MIX23
Protein MIX23

1

1

High-throughput

0.479

High

1148183

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1166777

MIC27
MICOS complex subunit MIC27

1

3

High-throughput

0.479

High

1191368

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

3

High-throughput

0.479

High

1236963

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

1264592

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

1

High-throughput

0.479

High

1268879

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1269430

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1281336

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1285855

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.479

High

1287972

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

3

High-throughput

0.479

High

1289285

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.479

High

1293927

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1294341

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

1297439

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

1302804

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.479

High

1303088

PHB2
Prohibitin-2

1

10

High-throughput

0.479

High

1303089

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.479

High

1303090

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1303091

MIC26
MICOS complex subunit MIC26

1

3

High-throughput

0.479

High

1303096

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1303100

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

1303102

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1303114

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.479

High

1303116

DJC11
DnaJ homolog subfamily C member 11

1

4

High-throughput

0.479

High

1303120

DJB12
DnaJ homolog subfamily B member 12

1

3

High-throughput

0.479

High

1303125

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.479

High

1303127

STML2
Stomatin-like protein 2, mitochondrial

1

2

High-throughput

0.479

High

1303131

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

1303133

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.479

High

1303135

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

834333

PSN1
Presenilin-1

1

0

Small-scale

0.460

High

264614

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

304761

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

Small-scale

0.458

High

371250

NU6M
NADH-ubiquinone oxidoreductase chain 6

1

0

Small-scale

0.458

High

388675

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

519817

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

736185

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

851960

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

864249

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

873067

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

949155

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

958508

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1052379

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.458

High

1088605

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1173917

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1188760

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1302738

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1303093

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.458

High

1303105

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.458

High

1303119

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

175132

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

1111

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

275463

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

1130477

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

556656

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.437

High

721238

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

779962

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

1029776

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1081373

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1123308

PKHG4
Puratrophin-1

1

1

High-throughput

0.437

High

1146764

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

1171362

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1224228

DOCK3
Dedicator of cytokinesis protein 3

1

2

High-throughput

0.437

High

1245913

DNJB8
DnaJ homolog subfamily B member 8

1

3

High-throughput

0.437

High

1303101

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.437

High

1303104

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1303106

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1303107

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.437

High

1303111

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.437

High

1303115

DUS22
Dual specificity protein phosphatase 22

1

5

High-throughput

0.437

High

1036836

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

155

A0A024R6X4
PLEKHG4

1

1

High-throughput

0.407

High

240152

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

402377

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

1017216

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

0

High-throughput

0.313

High

314775

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.282

High

546104

MYOG
Myogenin

1

0

High-throughput

0.282

High

236449

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.279

Low

540334

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.279

Low

1025681

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.279

Low

1132956

CSCL2
CSC1-like protein 2

1

0

High-throughput

0.279

Low

1170413

TBCD9
TBC1 domain family member 9

1

0

High-throughput

0.279

Low

1298381

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

High-throughput

0.279

Low

1303130

AP4E1
AP-4 complex subunit epsilon-1

1

0

High-throughput

0.279

Low

1303134

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

1165882

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1217076

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

1295788

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

Small-scale

0.249

Low

1299604

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.249

Low

1303092

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low

1303109

AKTIP
AKT-interacting protein

1

0

Small-scale

0.249

Low

1303122

RHG20
Rho GTPase-activating protein 20

1

0

High-throughput

0.249

Low

1303132

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1255803

Q8TE30
RNA-directed DNA polymerase

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024