Protein: YMEL1
ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)

Gene: YMEL1, YME1L1
Organism: Homo sapiens
Interactions: 189
UniProt ID: Q96TA2

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560063

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

High-throughput

0.640

High

396774

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

242679

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.618

High

1403721

CLPB
Mitochondrial disaggregase

1

5

High-throughput

0.618

High

1403727

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.618

High

1403753

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.618

High

1242906

S39A4
Zinc transporter ZIP4

2

4

High-throughput

0.601

High

412484

NTRK1
High affinity nerve growth factor receptor

2

4

High-throughput

0.594

High

292204

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

1

High-throughput

0.584

High

348676

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

2

High-throughput

0.584

High

1270614

COX15
Heme A synthase COX15

2

1

High-throughput

0.584

High

1403719

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

1

High-throughput

0.584

High

1403734

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

1403742

OCAD1
OCIA domain-containing protein 1

2

2

High-throughput

0.584

High

508486

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.579

High

944041

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.575

High

1403741

ATD3A
ATPase family AAA domain-containing protein 3A

1

11

High-throughput

0.575

High

1398991

ODAD4
Outer dynein arm-docking complex subunit 4

2

2

High-throughput

0.574

High

1259442

TBA1A
Tubulin alpha-1A chain

2

4

High-throughput

0.571

High

245521

OPA1
Dynamin-like GTPase OPA1, mitochondrial

2

0

High-throughput

0.559

High

342298

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.553

High

1403735

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.553

High

1403750

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

Small-scale

0.553

High

564261

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

585820

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

1

High-throughput

0.536

High

724704

MK04
Mitogen-activated protein kinase 4

1

2

High-throughput

0.536

High

846782

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.536

High

922280

LIMK1
LIM domain kinase 1

1

4

High-throughput

0.536

High

922330

LIMK2
LIM domain kinase 2

1

2

High-throughput

0.536

High

1034807

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

1123388

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1160954

PDK4
[Pyruvate dehydrogenase

1

2

High-throughput

0.536

High

1243042

PKN3
Serine/threonine-protein kinase N3

1

2

High-throughput

0.536

High

1286374

NEK8
Serine/threonine-protein kinase Nek8

1

1

High-throughput

0.536

High

1287603

ADCK1
AarF domain-containing protein kinase 1

1

3

High-throughput

0.536

High

1289366

ST32C
Serine/threonine-protein kinase 32C

1

2

High-throughput

0.536

High

1294674

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

1

High-throughput

0.536

High

1337126

HIPK4
Homeodomain-interacting protein kinase 4

1

2

High-throughput

0.536

High

1339913

NEK11
Serine/threonine-protein kinase Nek11

1

2

High-throughput

0.536

High

1341301

COQ8A
Atypical kinase COQ8A, mitochondrial

1

3

High-throughput

0.536

High

1372375

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1387053

COQ8B
Atypical kinase COQ8B, mitochondrial

1

3

High-throughput

0.536

High

1403723

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

1

High-throughput

0.536

High

1403736

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

1

High-throughput

0.536

High

1403745

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.536

High

1403747

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

2

High-throughput

0.536

High

1403748

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.533

High

1227320

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.521

High

1403760

DJC15
DnaJ homolog subfamily C member 15

1

3

High-throughput

0.515

High

125045

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

231004

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

251247

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.513

High

828434

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.513

High

1157622

ASIC2
Acid-sensing ion channel 2

1

0

High-throughput

0.513

High

1403718

STK33
Serine/threonine-protein kinase 33

1

0

High-throughput

0.513

High

1403732

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1403737

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

0

High-throughput

0.513

High

575696

GPIX
Platelet glycoprotein IX

1

1

High-throughput

0.489

High

1383443

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

1403752

INTU
Protein inturned

1

1

High-throughput

0.489

High

124454

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

216793

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.479

High

294216

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

296288

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

315916

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

318049

TOM70
Mitochondrial import receptor subunit TOM70

1

2

High-throughput

0.479

High

331253

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

360459

COX2
Cytochrome c oxidase subunit 2

1

2

Small-scale

0.479

High

372925

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

397644

NU2M
NADH-ubiquinone oxidoreductase chain 2

1

1

Small-scale

0.479

High

397756

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

1

Small-scale

0.479

High

404362

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

519204

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532890

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

589488

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

854914

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

899187

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

901513

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

988641

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

1114089

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1140733

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1149611

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

1196948

MIX23
Protein MIX23

1

1

High-throughput

0.479

High

1250103

MIC27
MICOS complex subunit MIC27

1

3

High-throughput

0.479

High

1279537

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

3

High-throughput

0.479

High

1330365

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

1361696

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

1

High-throughput

0.479

High

1366526

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1367089

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1384982

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.479

High

1387209

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

3

High-throughput

0.479

High

1388573

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

1

High-throughput

0.479

High

1393617

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1394046

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

1397630

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.479

High

1403391

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.479

High

1403711

PHB2
Prohibitin-2

1

10

High-throughput

0.479

High

1403712

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

1

High-throughput

0.479

High

1403713

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1403714

MIC26
MICOS complex subunit MIC26

1

3

High-throughput

0.479

High

1403720

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1403724

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

4

High-throughput

0.479

High

1403726

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1403738

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.479

High

1403740

DJC11
DnaJ homolog subfamily C member 11

1

4

High-throughput

0.479

High

1403744

DJB12
DnaJ homolog subfamily B member 12

1

3

High-throughput

0.479

High

1403749

SEC63
Translocation protein SEC63 homolog

1

3

High-throughput

0.479

High

1403751

STML2
Stomatin-like protein 2, mitochondrial

1

2

High-throughput

0.479

High

1403755

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

1403757

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.479

High

1403759

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

890037

PSN1
Presenilin-1

1

0

Small-scale

0.460

High

281646

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

326484

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

Small-scale

0.458

High

397771

NU6M
NADH-ubiquinone oxidoreductase chain 6

1

0

Small-scale

0.458

High

415808

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

553859

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

784877

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

785855

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

909469

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

922764

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

932505

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

1013440

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1023603

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1124788

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.458

High

1164522

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1252944

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1257988

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1403716

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.458

High

1403729

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.458

High

1403743

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

185949

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

1108

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

294747

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

1

High-throughput

0.445

High

430263

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

916331

TXTP
Tricarboxylate transport protein, mitochondrial

1

2

High-throughput

0.445

High

1209545

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

1236285

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1323755

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.445

High

1337923

ZNT7
Zinc transporter 7

1

1

High-throughput

0.445

High

1363426

S39A7
Zinc transporter SLC39A7

1

4

High-throughput

0.445

High

450344

ACBP
Acyl-CoA-binding protein

1

1

High-throughput

0.437

High

592883

CBR1
Carbonyl reductase [NADPH] 1

1

1

High-throughput

0.437

High

696297

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768971

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

831287

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

1100280

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1156828

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

1201876

PKHG4
Puratrophin-1

1

1

High-throughput

0.437

High

1229048

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1255189

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1316239

DOCK3
Dedicator of cytokinesis protein 3

1

2

High-throughput

0.437

High

1327145

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1340507

DNJB8
DnaJ homolog subfamily B member 8

1

3

High-throughput

0.437

High

1380108

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.437

High

1397333

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1403321

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.437

High

1403725

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.437

High

1403728

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1403730

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1403731

DOCK5
Dedicator of cytokinesis protein 5

1

1

High-throughput

0.437

High

1403739

DUS22
Dual specificity protein phosphatase 22

1

5

High-throughput

0.437

High

1108072

SQSTM
Sequestosome-1

1

0

High-throughput

0.426

High

155

A0A024R6X4
PLEKHG4

1

1

High-throughput

0.407

High

255180

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

1197868

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.407

High

1086681

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

2

0

High-throughput

0.313

High

337489

PSMG1
Proteasome assembly chaperone 1

1

0

High-throughput

0.282

High

581789

MYOG
Myogenin

1

0

High-throughput

0.282

High

1403722

BC11A
BCL11 transcription factor A

1

0

High-throughput

0.282

High

1095933

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.279

Low

1212288

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

1254231

TBCD9
TBC1 domain family member 9

1

0

High-throughput

0.279

Low

1398693

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

High-throughput

0.279

Low

1403754

AP4E1
AP-4 complex subunit epsilon-1

1

0

High-throughput

0.279

Low

1403758

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

1403717

RNF26
E3 ubiquitin-protein ligase RNF26

1

0

Small-scale

0.261

Low

1218638

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1249142

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1276685

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1308193

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.249

Low

1395640

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

Small-scale

0.249

Low

1399988

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.249

Low

1403715

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low

1403733

AKTIP
AKT-interacting protein

1

0

Small-scale

0.249

Low

1403746

RHG20
Rho GTPase-activating protein 20

1

0

High-throughput

0.249

Low

1403756

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1348808

S35G2
Solute carrier family 35 member G2

1

0

High-throughput

0.232

Low

1352092

Q8TE30
RNA-directed DNA polymerase

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025