HitPredict

Interactor 1: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26949739, 35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0031648 - protein destabilization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4128 Hs			1 768
+	Hs
		944230 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		944359 PRKDC_HUMAN (1-4128): 0: 6819: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1042913 TRRAP_HUMAN (2754-4128): 0: 828: 15.88		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041299 TRRAP_HUMAN (2754-4128): 0: 828: 15.88		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1031518 ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		787480 MTOR_HUMAN (2776-4127): 0: 695: 15.99		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1038110 ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28		CUL3_HUMAN (1-768): 0: 951: 100.00