HitPredict

Interactor 1: SSBP2 (P81877)
Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)
Gene: SSBP2

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 24981860, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 361 Hs			1 359
+	Hs
		899917 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		ISL1_HUMAN (14-358): 6.97e-87: 268: 73.91
+	Mm
		899943 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		ISL1_MOUSE (14-358): 6.97e-87: 268: 73.91
+	Mm
		1321867 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		ISL2_MOUSE (1-359): 3.88e-85: 263: 98.61
+	Mm
		1321891 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LHX2_MOUSE (24-326): 2.86e-58: 195: 27.76
+	Hs
		839725 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX2_HUMAN (24-326): 1.89e-57: 193: 27.20
+	Mm
		1321890 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LHX9_MOUSE (10-313): 9.15e-57: 191: 26.33
+	Hs
		903700 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LMO4_HUMAN (15-165): 1.69e-54: 178: 38.13
+	Mm
		903801 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LMO4_MOUSE (15-165): 1.69e-54: 178: 38.13
+	Mm
		1266179 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		RBTN1_MOUSE (17-154): 1.51e-53: 175: 36.17
+	Mm
		1207524 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LMO3_MOUSE (27-148): 1.53e-26: 104: 40.16
+	Hs
		946651 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LMO3_HUMAN (27-148): 1.53e-26: 104: 40.16
+	Hs
		638493 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		RBTN1_HUMAN (27-143): 3.27e-26: 103: 40.83
+	Hs
		946655 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX4_HUMAN (1-82): 3.14e-17: 83.9: 22.89
+	Mm
		1321889 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LMX1A_MOUSE (7-83): 5.09e-17: 83.5: 20.78
+	Mm
		292010 SSBP2_MOUSE (1-361): 8.29e-60: 198: 99.72		LMX1B_MOUSE (7-83): 1.26e-16: 82.3: 19.48
+	Hs
		238106 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LMX1B_HUMAN (7-83): 1.54e-16: 82: 19.48
+	Hs
		946671 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		822624 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX1_HUMAN (7-81): 9.53e-14: 73.9: 19.74
+	Hs
		946646 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX8_HUMAN (7-81): 1.2e-12: 70: 20.00
+	Hs
		946674 SSBP2_HUMAN (1-361): 6.02e-60: 198: 100.00		LHX6_HUMAN (7-81): 1.54e-11: 66.9: 20.00