Protein: TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)

Gene: TIRAP
Organism: Homo sapiens
Interactions: 55
UniProt ID: P58753

Gene Ontology (top 5):
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0005080 - protein kinase C binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

946675

MYD88
Myeloid differentiation primary response protein MyD88

14

6

Small-scale

0.984

High

946652

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

5

0

Small-scale

0.871

High

126301

TLR4
Toll-like receptor 4

12

3

Small-scale

0.761

High

946656

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

3

1

High-throughput

0.667

High

252339

TLR2
Toll-like receptor 2

3

3

Small-scale

0.664

High

946683

TRAF6
TNF receptor-associated factor 6

4

0

Small-scale

0.658

High

905533

IRAK1
Interleukin-1 receptor-associated kinase 1

2

3

High-throughput

0.649

High

946679

IRAK4
Interleukin-1 receptor-associated kinase 4

2

1

Small-scale

0.640

High

881759

DHYS
Deoxyhypusine synthase

3

0

High-throughput

0.638

High

946676

TEP1
Telomerase protein component 1

3

0

High-throughput

0.638

High

946677

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

3

0

High-throughput

0.638

High

946667

TCAM2
TIR domain-containing adapter molecule 2

1

0

Small-scale

0.631

High

210182

IRAK2
Interleukin-1 receptor-associated kinase-like 2

2

3

Small-scale

0.621

High

946664

SARM1
NAD(+) hydrolase SARM1

1

0

Small-scale

0.614

High

946657

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.611

High

193240

SOCS1
Suppressor of cytokine signaling 1

2

3

Small-scale

0.601

High

712846

CASP1
Caspase-1

2

0

Small-scale

0.599

High

946653

BTK
Tyrosine-protein kinase BTK

2

0

Small-scale

0.585

High

946663

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

0

High-throughput

0.577

High

317818

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.561

High

521266

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.561

High

946682

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.561

High

946659

RAGE
Advanced glycosylation end product-specific receptor

1

1

Small-scale

0.536

High

946668

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.536

High

946669

UBR2
E3 ubiquitin-protein ligase UBR2

1

1

High-throughput

0.536

High

421821

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.518

High

946655

MPP3
MAGUK p55 subfamily member 3

1

0

High-throughput

0.518

High

289478

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.513

High

637872

NF1
Neurofibromin

1

0

High-throughput

0.513

High

658669

JAK1
Tyrosine-protein kinase JAK1

1

0

High-throughput

0.513

High

827727

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.513

High

946662

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.513

High

946670

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.513

High

946680

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.513

High

946678

RN216
E3 ubiquitin-protein ligase RNF216

1

0

Small-scale

0.493

High

699669

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

834656

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

1

Small-scale

0.479

High

946658

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

946660

TLR1
Toll-like receptor 1

1

3

Small-scale

0.479

High

946666

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

1

Small-scale

0.479

High

946672

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

946674

BTBD9
BTB/POZ domain-containing protein 9

1

1

High-throughput

0.479

High

213881

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

624018

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

Small-scale

0.458

High

887882

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

946654

DNJC3
DnaJ homolog subfamily C member 3

1

0

Small-scale

0.458

High

946661

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

Small-scale

0.458

High

946665

KLH24
Kelch-like protein 24

1

0

High-throughput

0.458

High

946671

KAT2A
Histone acetyltransferase KAT2A

1

0

Small-scale

0.458

High

457073

CAN1
Calpain-1 catalytic subunit

1

0

Small-scale

0.426

High

946673

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.306

High

946681

TMED7
Transmembrane emp24 domain-containing protein 7

2

0

Small-scale

0.305

High

550946

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.282

High

863446

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025