Interactor 1: HTRA3 (P83110)
Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
Gene: HTRA3

Interactor 2: HTRA3 (P83110)
Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)
Gene: HTRA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.876

The method score is based on:

Property Details
Experiments 28642151, 26110759, 31899476
Identification Methods pull down, x-ray crystallography, molecular sieving
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IGFBP~Kazal_2, Kazal_2~Kazal_2, PDZ_6~PDZ_6, PDZ_6~Trypsin_2, Trypsin_2~Trypsin_2
Common GO terms GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0008236 - serine-type peptidase activity
and 2 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 453
Hs

1 453
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ss
+ At
+ Ec
+ Ec
+ Ec
+ Sp
+ Hs
+ Dr
+ At
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024