Protein: RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2)

Gene: RPAP2
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q8IXW5

Gene Ontology (top 5):
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

621912

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

High-throughput

0.930

High

667363

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

3

Small-scale

0.899

High

165059

RPC1
DNA-directed RNA polymerase III subunit RPC1

2

3

High-throughput

0.754

High

976112

RPB7
DNA-directed RNA polymerase II subunit RPB7

7

2

High-throughput

0.747

High

1313054

GPN1
GPN-loop GTPase 1

7

3

High-throughput

0.747

High

1313056

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

6

3

Small-scale

0.739

High

192835

RPB4
DNA-directed RNA polymerase II subunit RPB4

6

1

High-throughput

0.735

High

1313065

PIHD1
PIH1 domain-containing protein 1

10

0

Small-scale

0.722

High

912200

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

5

2

High-throughput

0.716

High

958990

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

4

1

High-throughput

0.699

High

621685

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

High-throughput

0.694

High

786713

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

1

High-throughput

0.691

High

1313069

UXT
Protein UXT

5

0

High-throughput

0.688

High

1313076

GPN3
GPN-loop GTPase 3

7

3

High-throughput

0.682

High

723017

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

3

High-throughput

0.667

High

912086

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

1

High-throughput

0.667

High

1313078

RUVB2
RuvB-like 2

3

1

High-throughput

0.667

High

316412

RMP
Unconventional prefoldin RPB5 interactor 1

4

0

High-throughput

0.657

High

132151

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

3

Small-scale

0.656

High

983676

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

1

High-throughput

0.650

High

1313035

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

2

3

Small-scale

0.649

High

1151269

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

High-throughput

0.646

High

305842

DXO
Decapping and exoribonuclease protein

3

0

High-throughput

0.638

High

1313075

PFD2
Prefoldin subunit 2

3

0

High-throughput

0.634

High

787759

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

2

High-throughput

0.628

High

1313047

RPAP3
RNA polymerase II-associated protein 3

3

0

High-throughput

0.628

High

1313058

PDRG1
p53 and DNA damage-regulated protein 1

3

0

High-throughput

0.628

High

1313059

MED17
Mediator of RNA polymerase II transcription subunit 17

3

0

High-throughput

0.628

High

506017

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

4

0

High-throughput

0.623

High

1108366

MED21
Mediator of RNA polymerase II transcription subunit 21

3

0

High-throughput

0.622

High

340004

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

High-throughput

0.618

High

262538

MCE1
mRNA-capping enzyme

3

0

High-throughput

0.613

High

1313055

MED4
Mediator of RNA polymerase II transcription subunit 4

3

0

High-throughput

0.613

High

923512

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.611

High

48986

MED19
Mediator of RNA polymerase II transcription subunit 19

3

0

High-throughput

0.606

High

244733

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

681866

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

1313028

CPNE2
Copine-2

2

0

High-throughput

0.602

High

1313040

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

High-throughput

0.602

High

1313066

ASB6
Ankyrin repeat and SOCS box protein 6

2

0

High-throughput

0.602

High

1313046

MED28
Mediator of RNA polymerase II transcription subunit 28

2

0

High-throughput

0.585

High

799280

BRCA1
Breast cancer type 1 susceptibility protein

2

1

High-throughput

0.584

High

1313062

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

3

High-throughput

0.584

High

1313051

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.580

High

1313061

RPC5
DNA-directed RNA polymerase III subunit RPC5

2

0

High-throughput

0.559

High

1313063

MED9
Mediator of RNA polymerase II transcription subunit 9

2

0

High-throughput

0.559

High

336010

MED26
Mediator of RNA polymerase II transcription subunit 26

2

0

High-throughput

0.547

High

1217591

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.536

High

1313041

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.536

High

1313045

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

3

High-throughput

0.536

High

1313050

ECT2
Protein ECT2

1

1

High-throughput

0.536

High

182155

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.513

High

219498

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.513

High

613391

VINC
Vinculin

1

0

High-throughput

0.513

High

649743

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

1100883

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1313026

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

1313027

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.513

High

1313030

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.513

High

1313037

CRML
Protein cramped-like

1

0

High-throughput

0.513

High

1313079

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

861677

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

High-throughput

0.501

High

1313032

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

High-throughput

0.501

High

1313038

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

1313043

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.489

High

173044

XPO1
Exportin-1

1

2

High-throughput

0.479

High

180334

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.479

High

239596

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

High-throughput

0.479

High

242229

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

284695

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

1

High-throughput

0.479

High

315765

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

316299

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

474808

VIME
Vimentin

1

1

High-throughput

0.479

High

610760

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

862287

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

876054

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.479

High

967845

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.479

High

1124271

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.479

High

1219114

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

1

High-throughput

0.479

High

1259049

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.479

High

1313024

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1313036

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

1313042

CDK19
Cyclin-dependent kinase 19

1

1

High-throughput

0.479

High

1313049

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.479

High

1313053

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

3

High-throughput

0.479

High

1313067

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

2

High-throughput

0.479

High

1313068

PHRF1
PHD and RING finger domain-containing protein 1

1

1

High-throughput

0.479

High

1313074

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.479

High

1313080

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

2

High-throughput

0.479

High

190987

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

282399

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.458

High

287460

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

287803

MED6
Mediator of RNA polymerase II transcription subunit 6

1

0

High-throughput

0.458

High

290071

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

302888

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.458

High

326355

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

341984

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

342244

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

406369

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

430629

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

437263

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

459670

PROF1
Profilin-1

1

0

High-throughput

0.458

High

615568

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

768606

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

769748

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.458

High

831037

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

873166

RXRG
Retinoic acid receptor RXR-gamma

1

0

High-throughput

0.458

High

896820

DYN2
Dynamin-2

1

0

High-throughput

0.458

High

952945

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

994645

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

1029874

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1067495

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1107902

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1149695

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

High-throughput

0.458

High

1156540

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.458

High

1229170

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1241391

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

1270300

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.458

High

1280875

CNTRL
Centriolin

1

0

High-throughput

0.458

High

1313018

INT1
Integrator complex subunit 1

1

0

High-throughput

0.458

High

1313019

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1313020

CE120
Centrosomal protein of 120 kDa

1

0

High-throughput

0.458

High

1313021

EHBP1
EH domain-binding protein 1

1

0

High-throughput

0.458

High

1313022

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1313023

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

1313029

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

1313031

INT4
Integrator complex subunit 4

1

0

High-throughput

0.458

High

1313039

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

1313044

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1313048

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1313052

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

1313057

HELLS
Lymphoid-specific helicase

1

0

High-throughput

0.458

High

1313060

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

1313070

ZO2
Tight junction protein 2

1

0

High-throughput

0.458

High

1313071

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1313072

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

High-throughput

0.458

High

1313073

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.458

High

1313077

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.458

High

1313081

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.458

High

117730

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.426

High

934840

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1109317

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.426

High

1231995

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

1257019

SYDE1
Rho GTPase-activating protein SYDE1

2

0

High-throughput

0.328

High

505960

MYZAP
Myocardial zonula adherens protein

2

0

High-throughput

0.313

High

1313034

DAA10
Dynein axonemal assembly factor 10

2

0

High-throughput

0.305

High

260723

RAMP1
Receptor activity-modifying protein 1

1

0

High-throughput

0.279

Low

387657

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

1022088

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

0

High-throughput

0.279

Low

1313025

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

106238

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1218296

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

0

High-throughput

0.249

Low

1313064

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

1313033

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025