HitPredict

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	25416956, 25910212, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0010629 - negative regulation of gene expression
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 197
+	Hs
		993416 SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00