HitPredict - High confidence protein-protein interactions

Interactor 1: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	11486006, 14741200, 12228247, 28471448
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000987 - cis-regulatory region sequence-specific DNA binding GO:0001217 - DNA-binding transcription repressor activity and 23 others more... GO:0001223 - transcription coactivator binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001666 - response to hypoxia GO:0001947 - heart looping GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0016922 - nuclear receptor binding GO:0019901 - protein kinase binding GO:0031625 - ubiquitin protein ligase binding GO:0032909 - regulation of transforming growth factor beta2 production GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0098586 - cellular response to virus GO:1902894 - negative regulation of miRNA transcription GO:1902895 - positive regulation of miRNA transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	425
Hs

1	826

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Last updated: 15 Jul 2024